SCHEMBL16369792

SCHEMBL16369792

O=C(O)c1cc(CBr)nc(CBr)c1

nearest known ligand 0.48

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ TSHR P16473 2/20 0.48
▸ ALOX15 P16050 1/20 0.48
▸ HIF1A Q16665 1/20 0.48
▸ TTR P02766 2/20 0.41
▸ CA12 O43570 2/20 0.41
▸ CA1 P00915 2/20 0.41
▸ CA2 P00918 2/20 0.41
▸ CA7 P43166 2/20 0.41
▸ CA9 Q16790 2/20 0.41
▸ CA14 Q9ULX7 2/20 0.41
▸ TPMT P51580 3/20 0.39
▸ TP53 P04637 2/20 0.39
▸ KDM4E B2RXH2 1/20 0.39
▸ ALDH1A1 P00352 1/20 0.39
▸ LMNA P02545 1/20 0.39
▸ CA3 P07451 1/20 0.39
▸ MAPT P10636 1/20 0.39
▸ SELL P14151 1/20 0.39
▸ HPGD P15428 1/20 0.39
▸ SELP P16109 1/20 0.39

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL25188688 0.83 MEN1 (0.54) KDM4EALDH1A1LMNATDP1MEN1
SCHEMBL8908305 0.80 TPMT (0.37) TSHRALOX15HIF1ATPMTALDH1A1
SCHEMBL30412517 0.80 BRD4 (0.40) TSHRLMNAMAPTSMN1; SMN2HSD17B10
SCHEMBL16369830 0.79 TSHR (0.50) TSHRALOX15HIF1ATTRCA12
SCHEMBL17987756 0.78 KDM4E (0.34) CA12CA1CA2CA7CA9
SCHEMBL17670461 0.77 TSHR (0.48) TSHRALOX15HIF1ATTRCA12
SCHEMBL1424790 0.77 ALOX15 (0.48) TSHRALOX15HIF1ACA12CA1
Hydrochloric Acid SCHEMBL1425679 0.76 ALOX15 (0.46) TSHRALOX15HIF1ACA12CA1
SCHEMBL28331934 0.75 KDM4C (0.55) KDM4EALDH1A1MAPTNAPRT
SCHEMBL30560163 0.75 KDM4C (0.55) KDM4EALDH1A1MAPTNAPRT

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 19 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20240342301-A1 ANTIBODY-DRUG CONJUGATES MC SAF (FR) 2024-10-17 — — US disclosed
CN-118251239-A Antibody-drug conjugates MC SAF公司 2024-06-25 — — CN disclosed
EP-4380625-A1 ANTIBODY-DRUG CONJUGATES Mc SAF (FR) 2024-06-12 — — EP disclosed
WO-2023012437-A1 ANTIBODY-DRUG CONJUGATES MC SAF (FR) 2023-02-09 — — WO disclosed
WO-2023012437-A1 ANTIBODY-DRUG CONJUGATES MC SAF (FR) 2023-02-09 — — WO disclosed
US-11278627-B2 Antibody-drug conjugates and the use of same in therapy MC SAF (FR) 2022-03-22 — — US disclosed
EP-3825304-A1 ANTIBODY-DRUG CONJUGATES AND THE USE OF SAME IN THERAPY Mc SAF (FR) 2021-05-26 — — EP disclosed
EP-3825304-A1 ANTIBODY-DRUG CONJUGATES AND THE USE OF SAME IN THERAPY Mc SAF (FR) 2021-05-26 — — EP disclosed
EP-3521314-B1 ANTIBODY-DRUG CONJUGATES AND USE THEREOF IN THERAPY MC SAF (FR) 2021-02-24 — — EP disclosed
EP-3521314-B1 ANTIBODY-DRUG CONJUGATES AND USE THEREOF IN THERAPY MC SAF (FR) 2021-02-24 — — EP disclosed
EP-3521314-A1 NEW ANTIBODY-DRUG CONJUGATES AND USE THEREOF IN TREATMENT Université François Rabelais (FR) 2019-08-07 — — EP disclosed
EP-3521314-A1 NEW ANTIBODY-DRUG CONJUGATES AND USE THEREOF IN TREATMENT Université François Rabelais (FR) 2019-08-07 — — EP disclosed
US-10307488-B2 Antibody-drug conjugates and the use of same in therapy UNIVERSITE FRANCOIS RABELAIS (FR) 2019-06-04 — — US disclosed
US-20160151515-A1 NOVEL ANTIBODY-DRUG CONJUGATES AND THE USE OF SAME IN THERAPY MC SAF (FR) 2016-06-02 — — US disclosed
US-20160151515-A1 NOVEL ANTIBODY-DRUG CONJUGATES AND THE USE OF SAME IN THERAPY MC SAF (FR) 2016-06-02 — — US disclosed
US-20160151515-A1 NOVEL ANTIBODY-DRUG CONJUGATES AND THE USE OF SAME IN THERAPY MC SAF (FR) 2016-06-02 — — US disclosed
EP-3019202-A1 NOVEL ANTIBODY-DRUG CONJUGATES AND THE USE OF SAME IN THERAPY Université François Rabelais (FR) 2016-05-18 — — EP disclosed
WO-2015004400-A1 NOVEL ANTIBODY-DRUG CONJUGATES AND THE USE OF SAME IN THERAPY UNIVERSITE FRANCOIS RABELAIS (FR) 2015-01-15 — — WO disclosed
WO-2015004400-A1 NOVEL ANTIBODY-DRUG CONJUGATES AND THE USE OF SAME IN THERAPY UNIVERSITE FRANCOIS RABELAIS (FR) 2015-01-15 — — WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20240342301-A1 ANTIBODY-DRUG CONJUGATES FCGRT, FCGR3B, FCGR2A TSHR 1462/4885ALOX15 3253/4885HIF1A 2522/4885
US-10307488-B2 Antibody-drug conjugates and the use of same in therapy CD47, TNFRSF9, VSIG8 TSHR 3329/4885ALOX15 2408/4885HIF1A 3064/4885
US-20160151515-A1 NOVEL ANTIBODY-DRUG CONJUGATES AND THE USE OF SAME IN THERAPY CD47, TNFRSF9, VSIG8 TSHR 3396/4885ALOX15 2490/4885HIF1A 3422/4885
US-11278627-B2 Antibody-drug conjugates and the use of same in therapy CD47, TNFRSF9, VSIG8 TSHR 3329/4885ALOX15 2408/4885HIF1A 3064/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.

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