Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
| ▸ | TSHR | P16473 | 1/20 | 0.33 |
| ▸ | DDB1 | Q16531 | 1/20 | 0.33 |
| ▸ | CRBN | Q96SW2 | 1/20 | 0.33 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.33 |
| ▸ | OPRL1 | P41146 | 1/20 | 0.33 |
| ▸ | DHFR | P00374 | 1/20 | 0.32 |
| ▸ | POLB | P06746 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17610576 | 0.73 | TACR1 (0.42) | ALDH1A1TSHRMEN1KMT2ANPSR1 | |
| SCHEMBL7532040 | 0.72 | FAAH (0.33) | MEN1KMT2APOLB | |
| SCHEMBL11115468 | 0.72 | TSHR (0.41) | TSHRKMT2ADHFR | |
| SCHEMBL31680308 | 0.70 | ALDH1A1 (0.34) | ALDH1A1TSHRMEN1KMT2ANPSR1 | |
| SCHEMBL7748243 | 0.69 | MEN1 (0.35) | ALDH1A1MEN1KMT2A | |
| SCHEMBL10728607 | 0.69 | TSHR (0.35) | ALDH1A1TSHRSIGMAR1OPRL1DHFR | |
| SCHEMBL29112123 | 0.68 | TACR1 (0.43) | ALDH1A1TSHRMEN1KMT2ANPSR1 | |
| SCHEMBL31369027 | 0.68 | ALDH1A1 (0.39) | ALDH1A1MEN1KMT2ANPSR1 | |
| SCHEMBL536142 | 0.67 | KDM4E (0.31) | TSHRMEN1KMT2ANPSR1 | |
| SCHEMBL13785487 | 0.67 | TSHR (0.36) | TSHROPRL1DHFR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3019196-A1 | COMBINATIONS OF HEPATITIS C VIRUS INHIBITORS | Bristol-Myers Squibb Company (US) | 2016-05-18 | — | — | EP | disclosed |
| WO-2015005901-A1 | COMBINATIONS OF HEPATITIS C VIRUS INHIBITORS | BRISTOL-MYERS SQUIBB COMPANY (US) | 2015-01-15 | — | — | WO | disclosed |