Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 7/20 | 0.57 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.57 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.45 |
| ▸ | CASP1 | P29466 | 1/20 | 0.45 |
| ▸ | GFER | P55789 | 3/20 | 0.44 |
| ▸ | POLB | P06746 | 1/20 | 0.44 |
| ▸ | CASP3 | P42574 | 1/20 | 0.44 |
| ▸ | SENP8 | Q96LD8 | 1/20 | 0.44 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.44 |
| ▸ | SENP6 | Q9GZR1 | 1/20 | 0.44 |
| ▸ | RAB9A | P51151 | 3/20 | 0.43 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.43 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.43 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.42 |
| ▸ | HPGD | P15428 | 4/20 | 0.42 |
| ▸ | HTT | P42858 | 3/20 | 0.42 |
| ▸ | LMNA | P02545 | 6/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.41 |
| ▸ | NPC1 | O15118 | 2/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16370140 | 1.00 | MAPT (0.57) | MAPTTDP1ALDH1A1CASP1GFER | |
| SCHEMBL24988733 | 0.84 | ALDH1A1 (0.45) | MAPTTDP1ALDH1A1GFERPOLB | |
| SCHEMBL6670064 | 0.81 | ALDH1A1 (0.51) | MAPTALDH1A1GFERPOLBCASP3 | |
| SCHEMBL19859062 | 0.80 | MAPT (0.57) | MAPTTDP1ALDH1A1CASP1GFER | |
| SCHEMBL30935544 | 0.80 | MAPT (0.57) | MAPTTDP1ALDH1A1CASP1GFER | |
| SCHEMBL14741800 | 0.80 | MAPT (0.57) | MAPTTDP1ALDH1A1CASP1GFER | |
| SCHEMBL25100436 | 0.76 | CYP2C19 (0.51) | MAPTALDH1A1GFERPOLBCASP3 | |
| SCHEMBL16370214 | 0.76 | TDP1 (0.52) | MAPTTDP1ALDH1A1CASP1GFER | |
| SCHEMBL16370215 | 0.76 | TDP1 (0.52) | MAPTTDP1ALDH1A1CASP1GFER | |
| SCHEMBL18866954 | 0.75 | MAPT (0.61) | MAPTTDP1ALDH1A1CASP1POLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2015004481-A1 | IMIDAZO-CONDENSED BICYCLES AS INHIBITORS OF DISCOIDIN DOMAIN RECEPTORS (DDRS) | ASTEX THERAPEUTICS LIMITED (GB) | 2015-01-15 | — | — | WO | disclosed |