Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 3/20 | 0.57 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.57 |
| ▸ | LMNA | P02545 | 2/20 | 0.53 |
| ▸ | GFER | P55789 | 1/20 | 0.53 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.53 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.53 |
| ▸ | RECQL | P46063 | 1/20 | 0.51 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.45 |
| ▸ | CASP1 | P29466 | 1/20 | 0.45 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.42 |
| ▸ | GAA | P10253 | 3/20 | 0.40 |
| ▸ | RAB9A | P51151 | 2/20 | 0.40 |
| ▸ | PRSS1 | P07477 | 1/20 | 0.39 |
| ▸ | PRSS2 | P07478 | 1/20 | 0.39 |
| ▸ | PRSS3 | P35030 | 1/20 | 0.39 |
| ▸ | KDM1A | O60341 | 7/20 | 0.39 |
| ▸ | NPC1 | O15118 | 1/20 | 0.37 |
| ▸ | TP53 | P04637 | 1/20 | 0.37 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.37 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19859062 | 1.00 | MAPT (0.57) | MAPTTDP1LMNAGFERKMT2A | |
| SCHEMBL14741800 | 1.00 | MAPT (0.57) | MAPTTDP1LMNAGFERKMT2A | |
| SCHEMBL19798095 | 0.84 | LMNA (0.49) | MAPTTDP1LMNAGFERKMT2A | |
| SCHEMBL7971868 | 0.83 | LMNA (0.66) | MAPTLMNAGFERKMT2AL3MBTL1 | |
| SCHEMBL16367706 | 0.83 | LMNA (0.66) | MAPTLMNAGFERKMT2AL3MBTL1 | |
| SCHEMBL17737724 | 0.83 | LMNA (0.66) | MAPTLMNAGFERKMT2AL3MBTL1 | |
| SCHEMBL31748721 | 0.80 | RECQL (0.61) | MAPTLMNAGFERKMT2AL3MBTL1 | |
| SCHEMBL16370140 | 0.80 | MAPT (0.57) | MAPTTDP1LMNAGFERKMT2A | |
| SCHEMBL16370141 | 0.80 | MAPT (0.57) | MAPTTDP1LMNAGFERKMT2A | |
| SCHEMBL4509810 | 0.78 | LMNA (0.51) | MAPTLMNAGFERKMT2AL3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4630424-A1 | COMPOUNDS AND COMPOSITIONS AS C-KIT KINASE INHIBITORS | Third Harmonic Bio, Inc. (US) | 2025-10-15 | — | — | EP | disclosed |
| WO-2024124002-A1 | COMPOUNDS AND COMPOSITIONS AS C-KIT KINASE INHIBITORS | THIRD HARMONIC BIO, INC. (US) | 2024-06-13 | — | — | WO | disclosed |