Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRM5 | P41594 | 2/20 | 0.55 |
| ▸ | P2RX7 | Q99572 | 5/20 | 0.44 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.42 |
| ▸ | DHODH | Q02127 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
| ▸ | PDE4B | Q07343 | 4/20 | 0.39 |
| ▸ | PDE4D | Q08499 | 3/20 | 0.39 |
| ▸ | PDE4A | P27815 | 2/20 | 0.39 |
| ▸ | PDE4C | Q08493 | 2/20 | 0.39 |
| ▸ | HCRTR1 | O43613 | 1/20 | 0.39 |
| ▸ | GRM1 | Q13255 | 1/20 | 0.39 |
| ▸ | ACKR3 | P25106 | 1/20 | 0.39 |
| ▸ | NPC1 | O15118 | 1/20 | 0.38 |
| ▸ | RAB9A | P51151 | 1/20 | 0.38 |
| ▸ | TAS1R3 | Q7RTX0 | 1/20 | 0.38 |
| ▸ | TAS1R1 | Q7RTX1 | 1/20 | 0.38 |
| ▸ | TAS1R2 | Q8TE23 | 1/20 | 0.38 |
| ▸ | DPP4 | P27487 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17799639 | 1.00 | GRM5 (0.55) | GRM5P2RX7EPHX2DHODHALDH1A1 | |
| SCHEMBL17799684 | 0.90 | P2RX7 (0.44) | GRM5P2RX7ALDH1A1SMN1; SMN2HCRTR1 | |
| SCHEMBL16371852 | 0.90 | P2RX7 (0.44) | GRM5P2RX7ALDH1A1SMN1; SMN2HCRTR1 | |
| SCHEMBL17799652 | 0.87 | HCRTR1 (0.45) | GRM5P2RX7ALDH1A1SMN1; SMN2HCRTR1 | |
| SCHEMBL16371880 | 0.87 | GRM5 (0.40) | GRM5P2RX7ALDH1A1SMN1; SMN2TAS1R3 | |
| SCHEMBL17799647 | 0.87 | GRM5 (0.40) | GRM5P2RX7ALDH1A1SMN1; SMN2TAS1R3 | |
| SCHEMBL17799688 | 0.86 | HCRTR1 (0.48) | GRM5P2RX7EPHX2HCRTR1 | |
| SCHEMBL17799715 | 0.85 | P2RX7 (0.43) | GRM5P2RX7ALDH1A1SMN1; SMN2ACKR3 | |
| SCHEMBL16372250 | 0.85 | P2RX7 (0.43) | GRM5P2RX7ALDH1A1SMN1; SMN2ACKR3 | |
| SCHEMBL19767307 | 0.84 | HCRTR1 (0.43) | GRM5P2RX7HCRTR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3019476-A1 | 4-MEMBERED RING CARBOXAMIDES USED AS NEMATICIDES | Syngenta Participations AG (CH) | 2016-05-18 | — | — | EP | disclosed |
| WO-2015003951-A1 | 4-MEMBERED RING CARBOXAMIDES USED AS NEMATICIDES | SYNGENTA PARTICIPATIONS AG (CH) | 2015-01-15 | — | — | WO | disclosed |