Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AKR1B10 | O60218 | 1/20 | 0.47 |
| ▸ | AKR1B1 | P15121 | 1/20 | 0.47 |
| ▸ | PTGDR2 | Q9Y5Y4 | 5/20 | 0.43 |
| ▸ | PTGER2 | P43116 | 1/20 | 0.41 |
| ▸ | PTGDR | Q13258 | 1/20 | 0.41 |
| ▸ | HTR6 | P50406 | 5/20 | 0.41 |
| ▸ | HRH1 | P35367 | 4/20 | 0.41 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.41 |
| ▸ | SIRT2 | Q8IXJ6 | 2/20 | 0.41 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.40 |
| ▸ | SIRT1 | Q96EB6 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16373178 | 0.92 | AKR1B10 (0.49) | AKR1B10AKR1B1PTGDR2PTGDRHTR6 | |
| SCHEMBL16373179 | 0.90 | AKR1B10 (0.61) | AKR1B10AKR1B1PTGDR2HTR6HRH1 | |
| SCHEMBL16373180 | 0.89 | AKR1B10 (0.44) | AKR1B10AKR1B1PTGDR2PTGER2PTGDR | |
| SCHEMBL16335746 | 0.85 | GRIN2B (0.46) | PTGDR2PTGER2PTGDRHTR6HRH1 | |
| SCHEMBL16968494 | 0.81 | SIRT2 (0.58) | AKR1B10AKR1B1PTGDR2PTGER2PTGDR | |
| SCHEMBL15537063 | 0.75 | AKR1B10 (0.53) | AKR1B10AKR1B1PTGDR2HTR6HRH1 | |
| SCHEMBL14067960 | 0.72 | AKR1B10 (0.50) | AKR1B10AKR1B1PTGDR2PTGER2PTGDR | |
| SCHEMBL16373181 | 0.72 | MAOA (0.63) | HTR6HRH1 | |
| SCHEMBL10773567 | 0.72 | AKR1B10 (0.52) | AKR1B10AKR1B1PTGDR2 | |
| SCHEMBL15547688 | 0.71 | SIRT2 (0.58) | AKR1B10AKR1B1PTGDR2HTR6HRH1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2014207241-A1 | NEW Na-SUBSTITUTED CARBOLINE COMPOUNDS USABLE FOR THE TREATMENT OF NEURODEGENERATIVE DISEASES | ALZPROTECT (FR) | 2014-12-31 | — | — | WO | disclosed |