Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LGALS8 | O00214 | 6/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | THRB | P10828 | 1/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.41 |
| ▸ | LMNA | P02545 | 2/20 | 0.41 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.40 |
| ▸ | CD69 | Q07108 | 2/20 | 0.39 |
| ▸ | PYGB | P11216 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
| ▸ | LGALS3 | P17931 | 1/20 | 0.36 |
| ▸ | LGALS4 | P56470 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7154639 | 0.89 | ALDH1A1 (0.52) | LGALS8ALDH1A1THRBMAPK1LMNA | |
| SCHEMBL8027243 | 0.89 | ALDH1A1 (0.52) | LGALS8ALDH1A1THRBMAPK1LMNA | |
| SCHEMBL29556423 | 0.89 | ALDH1A1 (0.52) | LGALS8ALDH1A1THRBMAPK1LMNA | |
| SCHEMBL7154645 | 0.89 | ALDH1A1 (0.52) | LGALS8ALDH1A1THRBMAPK1LMNA | |
| SCHEMBL16152123 | 0.81 | LGALS8 (0.51) | LGALS8ALDH1A1THRBMAPK1PTPN1 | |
| SCHEMBL16342089 | 0.81 | LGALS8 (0.51) | LGALS8ALDH1A1THRBMAPK1PTPN1 | |
| SCHEMBL13496092 | 0.81 | LGALS8 (0.51) | LGALS8ALDH1A1THRBMAPK1PTPN1 | |
| SCHEMBL15250843 | 0.81 | LGALS8 (0.51) | LGALS8ALDH1A1THRBMAPK1PTPN1 | |
| SCHEMBL16340826 | 0.81 | LGALS8 (0.51) | LGALS8ALDH1A1THRBMAPK1PTPN1 | |
| SCHEMBL7535550 | 0.79 | LGALS8 (0.50) | LGALS8ALDH1A1THRBMAPK1PTPN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8927507-B2 | Selective glycosidase inhibitors and uses thereof | MERCK SHARP & DOHME CORP. | 2015-01-06 | — | — | US | disclosed |
| US-20140107044-A1 | SELECTIVE GLYCOSIDASE INHIBITORS AND USES THEREOF | MERCK SHARP & DOHME CORP. (US) | 2014-04-17 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20140107044-A1 | SELECTIVE GLYCOSIDASE INHIBITORS AND USES THEREOF | ENGASE, OGA, GALE | LGALS8 342/4885ALDH1A1 1167/4885THRB 1956/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.