Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AOC3 | Q16853 | 2/20 | 0.55 |
| ▸ | HRH3 | Q9Y5N1 | 2/20 | 0.53 |
| ▸ | GRM5 | P41594 | 1/20 | 0.49 |
| ▸ | MEN1 | O00255 | 1/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.49 |
| ▸ | PRMT5 | O14744 | 2/20 | 0.47 |
| ▸ | WDR77 | Q9BQA1 | 2/20 | 0.47 |
| ▸ | CHRM5 | P08912 | 4/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22693538 | 0.87 | AOC3 (0.53) | AOC3HRH3GRM5MEN1KMT2A | |
| SCHEMBL8230310 | 0.83 | AOC3 (0.53) | AOC3HRH3GRM5MEN1KMT2A | |
| SCHEMBL22693606 | 0.82 | AOC3 (0.52) | AOC3GRM5MEN1KMT2A | |
| SCHEMBL16367611 | 0.82 | PRMT5 (0.48) | AOC3HRH3GRM5PRMT5WDR77 | |
| SCHEMBL2204112 | 0.82 | MEN1 (0.62) | AOC3GRM5MEN1KMT2A | |
| SCHEMBL22693539 | 0.78 | AOC3 (0.53) | AOC3HRH3GRM5MEN1KMT2A | |
| SCHEMBL16848201 | 0.77 | AOC3 (0.49) | AOC3HRH3PRMT5WDR77CHRM5 | |
| SCHEMBL14467156 | 0.77 | CHRM5 (0.46) | CHRM5 | |
| SCHEMBL30242535 | 0.75 | GRM5 (0.56) | AOC3HRH3GRM5MEN1KMT2A | |
| SCHEMBL1239457 | 0.75 | MAOB (0.60) | HRH3GRM5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3016943-B1 | HETEROARYL PYRIDONE AND AZA-PYRIDONE AMIDE COMPOUNDS | HOFFMANN LA ROCHE (CH) | 2019-08-21 | — | — | EP | disclosed |
| US-9326985-B2 | Heteroaryl pyridone and aza-pyridone amide compounds | GENENTECH, INC. (US) | 2016-05-03 | — | — | US | disclosed |
| US-20150011461-A1 | HETEROARYL PYRIDONE AND AZA-PYRIDONE AMIDE COMPOUNDS | GENENTECH, INC. (US) | 2015-01-08 | — | — | US | disclosed |
| WO-2015000949-A1 | HETEROARYL PYRIDONE AND AZA-PYRIDONE AMIDE COMPOUNDS | F. HOFFMANN-LA ROCHE AG (CH) | 2015-01-08 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20150011461-A1 | HETEROARYL PYRIDONE AND AZA-PYRIDONE AMIDE COMPOUNDS | BTK, TYK2, LCK | AOC3 1512/4885HRH3 523/4885GRM5 1867/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.