Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PRMT5 | O14744 | 2/20 | 0.48 |
| ▸ | WDR77 | Q9BQA1 | 2/20 | 0.48 |
| ▸ | HRH3 | Q9Y5N1 | 5/20 | 0.47 |
| ▸ | THRB | P10828 | 1/20 | 0.44 |
| ▸ | CHRM5 | P08912 | 3/20 | 0.41 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.41 |
| ▸ | ACACB | O00763 | 1/20 | 0.40 |
| ▸ | AOC3 | Q16853 | 2/20 | 0.39 |
| ▸ | CES1 | P23141 | 1/20 | 0.39 |
| ▸ | ITGB3 | P05106 | 1/20 | 0.38 |
| ▸ | ITGA2B | P08514 | 1/20 | 0.38 |
| ▸ | GRM5 | P41594 | 1/20 | 0.38 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.38 |
| ▸ | CRHR1 | P34998 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13322633 | 0.83 | GRM5 (0.51) | PRMT5WDR77HRH3ITGB3ITGA2B | |
| SCHEMBL16375197 | 0.82 | AOC3 (0.55) | PRMT5WDR77HRH3CHRM5AOC3 | |
| SCHEMBL12628111 | 0.76 | GRM5 (0.49) | GRM5 | |
| SCHEMBL25591487 | 0.75 | GRM5 (0.40) | HRH3ITGB3ITGA2BGRM5 | |
| SCHEMBL2741632 | 0.75 | GRM5 (0.40) | HRH3GRM5 | |
| SCHEMBL19887439 | 0.75 | SDCBP (0.46) | PRMT5WDR77GRM5 | |
| SCHEMBL4418583 | 0.74 | ITGB3 (0.43) | PRMT5WDR77THRBAOC3ITGB3 | |
| SCHEMBL29135309 | 0.73 | HRH3 (0.55) | PRMT5WDR77HRH3THRBCHRM5 | |
| SCHEMBL16848201 | 0.73 | AOC3 (0.49) | PRMT5WDR77HRH3CHRM5AOC3 | |
| SCHEMBL23068721 | 0.73 | AOC3 (0.75) | AOC3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9326985-B2 | Heteroaryl pyridone and aza-pyridone amide compounds | GENENTECH, INC. (US) | 2016-05-03 | — | — | US | disclosed |
| US-20150011461-A1 | HETEROARYL PYRIDONE AND AZA-PYRIDONE AMIDE COMPOUNDS | GENENTECH, INC. (US) | 2015-01-08 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20150011461-A1 | HETEROARYL PYRIDONE AND AZA-PYRIDONE AMIDE COMPOUNDS | BTK, TYK2, LCK | PRMT5 1364/4885WDR77 1437/4885HRH3 523/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.