Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Fenofibric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PPARA known ✓ | Q07869 | 12/20 | 1.00 |
| ▸ | PPARG | P37231 | 8/20 | 1.00 |
| ▸ | FABP2 | P12104 | 2/20 | 1.00 |
| ▸ | SLC22A12 | Q96S37 | 1/20 | 1.00 |
| ▸ | CYP1A2 | P05177 | 3/20 | 0.83 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.83 |
| ▸ | MEN1 | O00255 | 2/20 | 0.83 |
| ▸ | MAPT | P10636 | 2/20 | 0.83 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.83 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.83 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.83 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.67 |
| ▸ | HPGD | P15428 | 2/20 | 0.67 |
| ▸ | ABCB11 | O95342 | 2/20 | 0.67 |
| ▸ | TSHR | P16473 | 2/20 | 0.67 |
| ▸ | HTR2A | P28223 | 2/20 | 0.67 |
| ▸ | PMP22 | Q01453 | 2/20 | 0.67 |
| ▸ | USP2 | O75604 | 1/20 | 0.67 |
| ▸ | LMNA | P02545 | 1/20 | 0.67 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.67 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Fenofibric Acid SCHEMBL10967778 | 0.98 | PPARA (0.97) | PPARAPPARGFABP2SLC22A12CYP1A2 | |
| Fenofibric Acid SCHEMBL28478335 | 0.98 | PPARA (0.97) | PPARAPPARGFABP2SLC22A12CYP1A2 | |
| Fenofibric Acid SCHEMBL4756701 | 0.97 | PPARA (0.94) | PPARAPPARGFABP2SLC22A12CYP1A2 | |
| Fenofibric Acid SCHEMBL10967152 | 0.97 | PPARA (0.94) | PPARAPPARGFABP2SLC22A12CYP1A2 | |
| Fenofibric Acid SCHEMBL10967591 | 0.97 | PPARA (0.94) | PPARAPPARGFABP2SLC22A12CYP1A2 | |
| Clofibric Acid SCHEMBL2227936 | 0.91 | PPARA (1.00) | PPARAPPARGFABP2SLC22A12CYP1A2 | |
| Clofibric Acid SCHEMBL102826 | 0.91 | PPARA (1.00) | PPARAPPARGFABP2SLC22A12CYP1A2 | |
| Clofibric Acid SCHEMBL317991 | 0.90 | PPARA (0.96) | PPARAPPARGFABP2SLC22A12CYP1A2 | |
| Clofibric Acid SCHEMBL10634899 | 0.90 | PPARA (0.96) | PPARAPPARGFABP2SLC22A12CYP1A2 | |
| Clofibric Acid SCHEMBL28571877 | 0.90 | PPARA (0.96) | PPARAPPARGFABP2SLC22A12CYP1A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Appears in 7037 patents — a generic fragment claimed broadly, so it's down-weighted as IP noise. Top by claim status then date:
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4725479-A1 | PPAR AGONISTS FOR TREATMENT OF DISEASES ASSOCIATED WITH AATD | Max-Planck-Gesellschaft zur Förderung der Wissenschaften e.V. (DE) | 2026-04-15 | — | — | EP | claimed |
| US-12485102-B2 | Methods and compositions for treating cancer | THE WISTAR INSTITUTE OF ANATOMY AND BIOLOGY (US) | 2025-12-02 | — | — | US | claimed |
| US-20250345333-A1 | THERAPIES WITH PPAR AGONISTS AND FGFR4 INHIBITORS | TYRA BIOSCIENCES INC (US) | 2025-11-13 | — | — | US | claimed |
| WO-2025226325-A2 | IN VITRO SYSTEMS FOR GENERATION OF SKIN EQUIVALENTS AND USES THEREOF AND METHODS FOR DIAGNOSIS AND TREATMENT OF CONNECTIVE TISSUE DISORDERS | THE REGENTS OF THE UNIVERSITY OF COLORADO, A BODY CORPORATE (US) | 2025-10-30 | — | — | WO | claimed |
| WO-2025131019-A1 | COMPOSITIONS AND METHODS FOR INHIBITING EXPRESSION OF INHIBIN SUBUNIT BETA E (INHBE) | SHANGHAI ARGO BIOPHARMACEUTICAL CO., LTD. (CN) | 2025-06-26 | — | — | WO | claimed |
| EP-4572781-A2 | SYNERGISTIC INTERACTIONS FOR IMPROVED CANCER TREATMENT | The United States of America, as Represented By the Secretary, Department of Health and Human Services (US) | 2025-06-25 | — | — | EP | claimed |
| WO-2025106815-A1 | COMBINATION OF AN FGFR4 INHIBITOR WITH A PPAR AGONIST | TYRA BIOSCIENCES, INC. (US) | 2025-05-22 | — | — | WO | claimed |
| CN-119677509-A | Fibrate composition for the treatment of inflammation and neuroinflammation | 特瑞克思生物科学有限公司 | 2025-03-21 | — | — | CN | claimed |
| WO-2025053988-A2 | SYSTEMS AND METHODS FOR CONVERTING BIOMASS TO HYDROCHAR USING HYDROTHERMAL CARBONIZATION | ENOVERRA ENERGY & ENVIRONMENT INC. (US) | 2025-03-13 | — | — | WO | claimed |
| EP-4493178-A1 | FIBRATE COMPOSITIONS FOR TREATING INFLAMMATION AND NEUROINFLAMMATION | TRX Biosciences Limited (GB) | 2025-01-22 | — | — | EP | claimed |
| EP-0295637-B1 | LIPID REGULATING COMPOSITIONS | WARNER-LAMBERT COMPANY (US) | 1991-09-25 | — | — | EP | claimed |
| EP-0295637-A2 | Lipid regulating compositions | WARNER-LAMBERT COMPANY (US) | 1988-12-21 | — | — | EP | claimed |
| EP-0012804-B2 | Salts of a non toxic, activated anion exchange resin capable of establishing a stable binding with bile acids and 2-(4'-(p-chlorobenzoyl)-phenoxy)-2-(methyl)-propionic acid and pharmaceutical compositions comprising these salts | ALFA FARMACEUTICI S.p.A. (IT) | 1987-03-04 | — | — | EP | claimed |
| EP-0036218-B1 | SALTS OF THE 3-HYDROXY QUINUCLIDINE ESTERS OF A PHENOXYCARBOXYLIC ACID, A PROCESS FOR THE PREPARATION THEREOF, AND RELATED PHARMACEUTICAL COMPOSITIONS | D and D S.r.l. (IT) | 1985-07-31 | — | — | EP | claimed |
| EP-0002151-B1 | PROCESS FOR THE SYNTHESIS OF ESTERS OF PARACHLOROBENZOYL-PHENOXY-ISOBUTYRIC ACID | LABORATOIRES FOURNIER S.A. (FR) | 1983-05-25 | — | — | EP | claimed |
| US-4355166-A | Quinuclidinic ester and derivatives of phenoxycarboxylic acids | D AND D S.R.L. (IT) | 1982-10-19 | — | — | US | claimed |
| EP-0012804-B1 | Salts of a non toxic, activated anion exchange resin capable of establishing a stable binding with bile acids and 2-(4'-(p-chlorobenzoyl)-phenoxy)-2-(methyl)-propionic acid and pharmaceutical compositions comprising these salts | ALFA FARMACEUTICI S.p.A. (IT) | 1981-12-30 | — | — | EP | claimed |
| EP-0036218-A2 | Salts of the 3-hydroxy quinuclidine esters of a phenoxycarboxylic acid, a process for the preparation thereof, and related pharmaceutical compositions | D and D S.r.l. (IT) | 1981-09-23 | — | — | EP | claimed |
| EP-0012804-A1 | Salts of a non toxic, activated anion exchange resin capable of establishing a stable binding with bile acids and 2-(4'-(p-chlorobenzoyl)-phenoxy)-2-(methyl)-propionic acid and pharmaceutical compositions comprising these salts | ALFA FARMACEUTICI S.p.A. (IT) | 1980-07-09 | — | — | EP | claimed |
| US-4146728-A | Esters of 2-[4-(4-chlorobenzoyl)-phenoxy-2-methyl-propionic acid with bis-(hydroxyalkylthio)-alkanes | LABORATOIRE L. LAFON (FR) | 1979-03-27 | — | — | US | claimed |