Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Fenofibric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PPARA known ✓ | Q07869 | 12/20 | 0.94 |
| ▸ | PPARG | P37231 | 8/20 | 0.94 |
| ▸ | FABP2 | P12104 | 2/20 | 0.94 |
| ▸ | SLC22A12 | Q96S37 | 1/20 | 0.94 |
| ▸ | CYP1A2 | P05177 | 3/20 | 0.78 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.78 |
| ▸ | MEN1 | O00255 | 2/20 | 0.78 |
| ▸ | MAPT | P10636 | 2/20 | 0.78 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.78 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.78 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.78 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.63 |
| ▸ | HPGD | P15428 | 2/20 | 0.63 |
| ▸ | ABCB11 | O95342 | 2/20 | 0.63 |
| ▸ | TSHR | P16473 | 2/20 | 0.63 |
| ▸ | HTR2A | P28223 | 2/20 | 0.63 |
| ▸ | PMP22 | Q01453 | 2/20 | 0.63 |
| ▸ | USP2 | O75604 | 1/20 | 0.63 |
| ▸ | LMNA | P02545 | 1/20 | 0.63 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.63 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Fenofibric Acid SCHEMBL16377 | 0.97 | PPARA (1.00) | PPARAPPARGFABP2SLC22A12CYP1A2 | |
| Fenofibric Acid SCHEMBL10967778 | 0.95 | PPARA (0.97) | PPARAPPARGFABP2SLC22A12CYP1A2 | |
| Fenofibric Acid SCHEMBL28478335 | 0.95 | PPARA (0.97) | PPARAPPARGFABP2SLC22A12CYP1A2 | |
| Fenofibric Acid SCHEMBL4756701 | 0.94 | PPARA (0.94) | PPARAPPARGFABP2SLC22A12CYP1A2 | |
| Fenofibric Acid SCHEMBL10967152 | 0.94 | PPARA (0.94) | PPARAPPARGFABP2SLC22A12CYP1A2 | |
| Clofibric Acid SCHEMBL2227936 | 0.88 | PPARA (1.00) | PPARAPPARGFABP2SLC22A12CYP1A2 | |
| Clofibric Acid SCHEMBL102826 | 0.88 | PPARA (1.00) | PPARAPPARGFABP2SLC22A12CYP1A2 | |
| Clofibric Acid SCHEMBL317991 | 0.87 | PPARA (0.96) | PPARAPPARGFABP2SLC22A12CYP1A2 | |
| Clofibric Acid SCHEMBL10634899 | 0.87 | PPARA (0.96) | PPARAPPARGFABP2SLC22A12CYP1A2 | |
| Clofibric Acid SCHEMBL28571877 | 0.87 | PPARA (0.96) | PPARAPPARGFABP2SLC22A12CYP1A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0036218-B1 | SALTS OF THE 3-HYDROXY QUINUCLIDINE ESTERS OF A PHENOXYCARBOXYLIC ACID, A PROCESS FOR THE PREPARATION THEREOF, AND RELATED PHARMACEUTICAL COMPOSITIONS | D and D S.r.l. (IT) | 1985-07-31 | — | — | EP | claimed |
| US-4355166-A | Quinuclidinic ester and derivatives of phenoxycarboxylic acids | D AND D S.R.L. (IT) | 1982-10-19 | — | — | US | claimed |
| EP-0036218-A2 | Salts of the 3-hydroxy quinuclidine esters of a phenoxycarboxylic acid, a process for the preparation thereof, and related pharmaceutical compositions | D and D S.r.l. (IT) | 1981-09-23 | — | — | EP | claimed |
| EP-0036218-B1 | SALTS OF THE 3-HYDROXY QUINUCLIDINE ESTERS OF A PHENOXYCARBOXYLIC ACID, A PROCESS FOR THE PREPARATION THEREOF, AND RELATED PHARMACEUTICAL COMPOSITIONS | D and D S.r.l. (IT) | 1985-07-31 | — | — | EP | disclosed |
| US-4355166-A | Quinuclidinic ester and derivatives of phenoxycarboxylic acids | D AND D S.R.L. (IT) | 1982-10-19 | — | — | US | disclosed |
| EP-0036218-A2 | Salts of the 3-hydroxy quinuclidine esters of a phenoxycarboxylic acid, a process for the preparation thereof, and related pharmaceutical compositions | D and D S.r.l. (IT) | 1981-09-23 | — | — | EP | disclosed |