Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.32 |
| ▸ | GLO1 | Q04760 | 1/20 | 0.31 |
| ▸ | MGAM | O43451 | 1/20 | 0.30 |
| ▸ | GAA | P10253 | 1/20 | 0.30 |
| ▸ | SI | P14410 | 1/20 | 0.30 |
| ▸ | MGAM2 | Q2M2H8 | 1/20 | 0.30 |
| ▸ | EIF2AK1 | Q9BQI3 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16377513 | 0.83 | GLO1 (0.33) | HSP90AA1GLO1MGAMGAASI | |
| SCHEMBL16377514 | 0.81 | MAPT (0.34) | HSP90AA1GLO1MGAMGAASI | |
| SCHEMBL16377501 | 0.73 | HSP90AA1 (0.39) | HSP90AA1GAA | |
| SCHEMBL1342355 | 0.69 | JAK1 (0.32) | HSP90AA1GAA | |
| SCHEMBL12553694 | 0.65 | SIRT5 (0.31) | GAA | |
| SCHEMBL1148560 | 0.64 | PIK3CD (0.38) | MGAMGAASIMGAM2 | |
| SCHEMBL12553693 | 0.62 | CHEK1 (0.36) | HSP90AA1GAA | |
| SCHEMBL1148655 | 0.62 | CA12 (0.35) | HSP90AA1GAA | |
| SCHEMBL1342318 | 0.61 | SIRT5 (0.35) | HSP90AA1GAA | |
| SCHEMBL12553695 | 0.61 | ESR1 (0.39) | HSP90AA1GAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8921407-B2 | Pyrazole compounds that modulate HSP90 activity | SYNTA PHARMACEUTICALS CORP. (US) | 2014-12-30 | — | — | US | disclosed |