Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.66 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.66 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.66 |
| ▸ | HSD11B1 | P28845 | 4/20 | 0.50 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.48 |
| ▸ | SLC9A1 | P19634 | 1/20 | 0.48 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.48 |
| ▸ | ASIC3 | Q9UHC3 | 1/20 | 0.47 |
| ▸ | AURKA | O14965 | 1/20 | 0.47 |
| ▸ | PDPK1 | O15530 | 1/20 | 0.47 |
| ▸ | RPS6KB1 | P23443 | 1/20 | 0.47 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.47 |
| ▸ | PDE3B | Q13370 | 1/20 | 0.46 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.46 |
| ▸ | TTR | P02766 | 1/20 | 0.45 |
| ▸ | EML4 | Q9HC35 | 1/20 | 0.45 |
| ▸ | ALK | Q9UM73 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3533360 | 0.87 | TTR (0.59) | KDM4EALDH1A1HSD17B10ASIC3PDE3B | |
| SCHEMBL1397423 | 0.87 | ALDH1A1 (0.55) | KDM4EALDH1A1HSD17B10HSD11B1CYP3A4 | |
| SCHEMBL1397495 | 0.86 | SLC9A1 (0.52) | KDM4EALDH1A1HSD17B10HSD11B1CYP3A4 | |
| SCHEMBL31003567 | 0.86 | KDM4E (0.48) | KDM4EALDH1A1HSD17B10CYP3A4SLC9A1 | |
| Hydrochloric Acid SCHEMBL4285100 | 0.86 | TTR (0.57) | KDM4EALDH1A1HSD17B10ASIC3PDE3B | |
| SCHEMBL16380652 | 0.85 | CHRM1 (0.48) | KDM4EALDH1A1HSD17B10HSD11B1CYP3A4 | |
| SCHEMBL3309679 | 0.85 | KDM4E (0.47) | KDM4EALDH1A1HSD17B10HSD11B1CYP3A4 | |
| SCHEMBL8261930 | 0.85 | CTPS1 (0.62) | KDM4EALDH1A1HSD17B10HSD11B1SLC9A1 | |
| SCHEMBL3309681 | 0.85 | ALDH1A1 (0.47) | KDM4EALDH1A1HSD17B10HSD11B1CYP3A4 | |
| SCHEMBL4278043 | 0.84 | WDR5 (0.52) | KDM4EALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2014206344-A1 | FUSED TRICYCLIC AMIDE COMPOUNDS AS MULTIPLE KINASE INHIBITORS | BEIGENE, LTD. (GB) | 2014-12-31 | — | — | WO | disclosed |