Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IP6K1 | Q92551 | 3/20 | 0.56 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.48 |
| ▸ | HPGD | P15428 | 1/20 | 0.48 |
| ▸ | DUSP3 | P51452 | 1/20 | 0.48 |
| ▸ | PTPN5 | P54829 | 1/20 | 0.48 |
| ▸ | PTPN11 | Q06124 | 1/20 | 0.48 |
| ▸ | DDR1 | Q08345 | 3/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.44 |
| ▸ | POLB | P06746 | 1/20 | 0.44 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.44 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.43 |
| ▸ | LMNA | P02545 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 1/20 | 0.43 |
| ▸ | NPC1 | O15118 | 1/20 | 0.43 |
| ▸ | TP53 | P04637 | 1/20 | 0.43 |
| ▸ | RAB9A | P51151 | 1/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18922209 | 0.89 | ALDH1A1 (0.57) | IP6K1ALDH1A1DDR1KDM4EPOLB | |
| SCHEMBL16380731 | 0.84 | KMT2A (0.53) | IP6K1ALDH1A1KDM4ELMNAMAPT | |
| SCHEMBL3992921 | 0.84 | IP6K1 (0.52) | IP6K1ALDH1A1DDR1KDM4ETP53 | |
| SCHEMBL16380631 | 0.83 | GFER (0.49) | IP6K1ALDH1A1DUSP3PTPN5PTPN11 | |
| SCHEMBL16380724 | 0.83 | ALDH1A1 (0.48) | IP6K1ALDH1A1KDM4EPOLBTDP1 | |
| SCHEMBL4264923 | 0.83 | CYP2A13 (0.62) | IP6K1ALDH1A1HPGDPOLBLMNA | |
| SCHEMBL16380640 | 0.81 | MAPK1 (0.51) | ALDH1A1DUSP3KDM4EPOLBTDP1 | |
| SCHEMBL3311056 | 0.80 | NR1H2 (0.52) | DDR1 | |
| SCHEMBL2776747 | 0.79 | ALDH1A1 (0.59) | ALDH1A1POLBLMNAMAPTNPC1 | |
| SCHEMBL1696442 | 0.78 | SLC6A4 (0.50) | KDM4ELMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9670231-B2 | Fused tricyclic amide compounds as multiple kinase inhibitors | BEIGENE, LTD. (KY) | 2017-06-06 | — | — | US | disclosed |
| WO-2014206344-A1 | FUSED TRICYCLIC AMIDE COMPOUNDS AS MULTIPLE KINASE INHIBITORS | BEIGENE, LTD. (GB) | 2014-12-31 | — | — | WO | disclosed |