Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.57 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.57 |
| ▸ | POLB | P06746 | 1/20 | 0.57 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.57 |
| ▸ | IP6K1 | Q92551 | 3/20 | 0.56 |
| ▸ | DDR1 | Q08345 | 1/20 | 0.53 |
| ▸ | CHKA | P35790 | 1/20 | 0.52 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.51 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.48 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.48 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.44 |
| ▸ | MAP3K11 | Q16584 | 1/20 | 0.43 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.43 |
| ▸ | CSF1R | P07333 | 1/20 | 0.43 |
| ▸ | KIT | P10721 | 1/20 | 0.43 |
| ▸ | JAK2 | O60674 | 1/20 | 0.43 |
| ▸ | JAK1 | P23458 | 1/20 | 0.43 |
| ▸ | TYK2 | P29597 | 1/20 | 0.43 |
| ▸ | JAK3 | P52333 | 1/20 | 0.43 |
| ▸ | ABL1 | P00519 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16380773 | 0.89 | IP6K1 (0.56) | ALDH1A1KDM4EPOLBTDP1IP6K1 | |
| SCHEMBL4889004 | 0.87 | ALDH1A1 (0.58) | ALDH1A1KDM4EPOLBTDP1IP6K1 | |
| SCHEMBL19192738 | 0.87 | ALDH1A1 (0.58) | ALDH1A1KDM4EPOLBTDP1DDR1 | |
| SCHEMBL27824318 | 0.87 | ALDH1A1 (0.58) | ALDH1A1KDM4EPOLBTDP1IP6K1 | |
| Hydrochloric Acid SCHEMBL3567586 | 0.86 | ALDH1A1 (0.57) | ALDH1A1KDM4EPOLBTDP1IP6K1 | |
| SCHEMBL4702839 | 0.84 | ALDH1A1 (0.49) | ALDH1A1KDM4EIP6K1ADORA1HDAC6 | |
| SCHEMBL3992921 | 0.84 | IP6K1 (0.52) | ALDH1A1KDM4EIP6K1DDR1 | |
| SCHEMBL9939410 | 0.84 | CHKA (0.57) | ALDH1A1KDM4EPOLBTDP1DDR1 | |
| SCHEMBL4264923 | 0.83 | CYP2A13 (0.62) | ALDH1A1POLBIP6K1HSD17B10JAK2 | |
| SCHEMBL16380634 | 0.83 | DDR1 (0.52) | ALDH1A1KDM4EIP6K1DDR1ADORA1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9670231-B2 | Fused tricyclic amide compounds as multiple kinase inhibitors | BEIGENE, LTD. (KY) | 2017-06-06 | — | — | US | disclosed |