SCHEMBL16383496

SCHEMBL16383496

O=C(O)c1cccc2oc(-c3ccc(O)cc3)nc12

nearest known ligand 0.54

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
TOP2A P11388 2/20 0.54
PARP1 P09874 1/20 0.52
ESR2 Q92731 4/20 0.50
DHODH Q02127 1/20 0.48
ESR1 P03372 3/20 0.46
HSPD1 P10809 1/20 0.45
PTPN1 P18031 1/20 0.45
PTPN5 P54829 1/20 0.45
HSPE1 P61604 1/20 0.45
IDO1 P14902 1/20 0.45
MAOA P21397 1/20 0.45
MAOB P27338 1/20 0.45
HTR3A P46098 3/20 0.45
BCHE P06276 1/20 0.43
NPC1 O15118 2/20 0.42
RAB9A P51151 2/20 0.42
ALDH1A1 P00352 2/20 0.42
KDM4E B2RXH2 1/20 0.42
MAPT P10636 1/20 0.42
HPGD P15428 1/20 0.42

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL28926584 0.94 TOP2A (0.59) TOP2APARP1DHODHIDO1MAOA
SCHEMBL121325 0.89 TOP2A (0.65) TOP2ADHODHIDO1MAOAMAOB
SCHEMBL205351 0.87 TOP2A (0.53) TOP2ADHODHIDO1MAOAMAOB
SCHEMBL120321 0.87 HTR3A (0.54) TOP2ADHODHHSPD1PTPN1PTPN5
SCHEMBL206232 0.87 TOP2A (0.56) TOP2ADHODHPTPN1PTPN5IDO1
SCHEMBL121392 0.87 HTR3A (0.54) TOP2ADHODHHSPD1PTPN1PTPN5
SCHEMBL2961027 0.85 TOP2A (0.54) TOP2ADHODHIDO1MAOAMAOB
SCHEMBL2957072 0.83 TOP2A (0.59) TOP2APARP1PTPN1PTPN5HTR3A
SCHEMBL2963234 0.83 TOP2A (0.50) TOP2APARP1DHODHHSPD1PTPN1
SCHEMBL2954629 0.83 TOP2A (0.53) TOP2APARP1DHODHPTPN1IDO1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2421823-B1 AZETIDINYL DIAMIDES AS MONOACYLGLYCEROL LIPASE INHIBITORS JANSSEN PHARMACEUTICA NV (BE) 2015-01-14 EP disclosed