Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4A | O75164 | 1/20 | 0.40 |
| ▸ | KDM4C | Q9H3R0 | 1/20 | 0.40 |
| ▸ | HDAC6 | Q9UBN7 | 4/20 | 0.38 |
| ▸ | KISS1R | Q969F8 | 1/20 | 0.36 |
| ▸ | EPHX1 | P07099 | 2/20 | 0.35 |
| ▸ | EPHX2 | P34913 | 2/20 | 0.33 |
| ▸ | BCHE | P06276 | 2/20 | 0.33 |
| ▸ | ACHE | P22303 | 2/20 | 0.33 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.33 |
| ▸ | PAOX | Q6QHF9 | 1/20 | 0.33 |
| ▸ | PRMT3 | O60678 | 1/20 | 0.32 |
| ▸ | CARM1 | Q86X55 | 1/20 | 0.32 |
| ▸ | PRMT6 | Q96LA8 | 1/20 | 0.32 |
| ▸ | PRMT1 | Q99873 | 1/20 | 0.32 |
| ▸ | PRMT8 | Q9NR22 | 1/20 | 0.32 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.32 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.31 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.31 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.31 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23568414 | 1.00 | KDM4A (0.40) | KDM4AKDM4CHDAC6KISS1REPHX1 | |
| SCHEMBL24607219 | 0.98 | KDM4A (0.38) | KDM4AKDM4CHDAC6KISS1REPHX1 | |
| SCHEMBL22151226 | 0.92 | KISS1R (0.38) | KDM4AKDM4CHDAC6KISS1RPAOX | |
| SCHEMBL12457054 | 0.84 | KDM4A (0.34) | KDM4AKDM4CHDAC6KISS1R | |
| SCHEMBL13096282 | 0.84 | PRMT6 (0.42) | KDM4AKDM4CHDAC6KISS1RPRMT3 | |
| SCHEMBL23696191 | 0.84 | HDAC6 (0.37) | HDAC6EPHX1EPHX2BCHEACHE | |
| SCHEMBL23696200 | 0.83 | KDM4E (0.34) | KDM4AKDM4CHDAC6KISS1RKDM4E | |
| SCHEMBL24673637 | 0.82 | CYP2C19 (0.39) | HDAC6EPHX1EPHX2BCHEACHE | |
| SCHEMBL23560446 | 0.81 | HDAC6 (0.35) | HDAC6EPHX1EPHX2BCHEACHE | |
| SCHEMBL16384400 | 0.80 | ALDH1A1 (0.48) | KDM4AKDM4CHDAC6PAOXSIGMAR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20150005319-A1 | MACROCYCLIC COMPOUNDS FOR MODULATING IL-17 | ENSEMBLE THERAPEUTICS CORPORATION | 2015-01-01 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20150005319-A1 | MACROCYCLIC COMPOUNDS FOR MODULATING IL-17 | IL17A, IL15, IL2 | KDM4A 3807/4885KDM4C 3635/4885HDAC6 190/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.