Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTT | P42858 | 2/20 | 0.34 |
| ▸ | MEN1 | O00255 | 2/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.34 |
| ▸ | CD38 | P28907 | 4/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.33 |
| ▸ | RAB9A | P51151 | 1/20 | 0.33 |
| ▸ | LMNA | P02545 | 5/20 | 0.32 |
| ▸ | CYP1A2 | P05177 | 4/20 | 0.32 |
| ▸ | HIF1A | Q16665 | 4/20 | 0.32 |
| ▸ | KDR | P35968 | 2/20 | 0.32 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.32 |
| ▸ | ABCC4 | O15439 | 1/20 | 0.32 |
| ▸ | USP2 | O75604 | 1/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.32 |
| ▸ | ABL1 | P00519 | 1/20 | 0.32 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.32 |
| ▸ | PIK3C3 | Q8NEB9 | 1/20 | 0.32 |
| ▸ | BCHE | P06276 | 1/20 | 0.32 |
| ▸ | HPGD | P15428 | 1/20 | 0.32 |
| ▸ | AGPAT2 | O15120 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16386425 | 0.84 | DYRK1A (0.38) | HTTMEN1KMT2ACD38SMN1; SMN2 | |
| SCHEMBL23711614 | 0.77 | PIK3C3 (0.40) | HTTMEN1KMT2ASMN1; SMN2RAB9A | |
| SCHEMBL27845951 | 0.73 | MEN1 (0.55) | HTTMEN1KMT2ASMN1; SMN2RAB9A | |
| SCHEMBL18711719 | 0.70 | KDR (0.45) | CD38SMN1; SMN2KDRALDH1A1MAPK1 | |
| SCHEMBL2910688 | 0.69 | LMNA (0.47) | HTTMEN1KMT2ASMN1; SMN2LMNA | |
| SCHEMBL4840039 | 0.68 | DYRK1A (0.35) | CD38KDRMAPK1TUBB4ATUBB | |
| SCHEMBL25144054 | 0.68 | LMNA (0.36) | MEN1KMT2ALMNAALDH1A1MAPK1 | |
| SCHEMBL23711611 | 0.67 | F2 (0.31) | LMNAALDH1A1 | |
| SCHEMBL23718561 | 0.67 | F2 (0.31) | KMT2ALMNAALDH1A1 | |
| SCHEMBL23711797 | 0.67 | ALDH1A1 (0.30) | LMNAALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 30 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11220504-B2 | Pyrrolo[3,2-d] pyrimidine derivatives for the treatment of viral infections and other diseases | Janssen Sciences Ireland Unlimited Company (IE) | 2022-01-11 | — | — | US | disclosed |
| US-11220504-B2 | Pyrrolo[3,2-d] pyrimidine derivatives for the treatment of viral infections and other diseases | Janssen Sciences Ireland Unlimited Company (IE) | 2022-01-11 | — | — | US | disclosed |
| US-10781216-B2 | Pyrrolo [3,2-d]pyrimidine derivatives for the treatment of viral infections and other diseases | Janssen Sciences Ireland Unlimited Company (IE) | 2020-09-22 | — | — | US | disclosed |
| US-10781216-B2 | Pyrrolo [3,2-d]pyrimidine derivatives for the treatment of viral infections and other diseases | Janssen Sciences Ireland Unlimited Company (IE) | 2020-09-22 | — | — | US | disclosed |
| US-20190330217-A1 | PYRROLO[3,2-D]PYRIMIDINE DERIVATIVES FOR THE TREATMENT OF VIRAL INFECTIONS AND OTHER DISEASES | Janssen Sciences Ireland Unlimited Company (IE) | 2019-10-31 | — | — | US | disclosed |
| US-20190330217-A1 | PYRROLO[3,2-D]PYRIMIDINE DERIVATIVES FOR THE TREATMENT OF VIRAL INFECTIONS AND OTHER DISEASES | Janssen Sciences Ireland Unlimited Company (IE) | 2019-10-31 | — | — | US | disclosed |
| US-10385054-B2 | Pyrrolo[3,2-d]pyrimidine derivatives for the treatment of viral infections and other diseases | Janssen Sciences Ireland Unlimited Company (IE) | 2019-08-20 | — | — | US | disclosed |
| US-10385054-B2 | Pyrrolo[3,2-d]pyrimidine derivatives for the treatment of viral infections and other diseases | Janssen Sciences Ireland Unlimited Company (IE) | 2019-08-20 | — | — | US | disclosed |
| US-10259814-B2 | Pyrrolo[3,2-d]pyrimidine derivatives for the treatment of viral infections and other diseases | JANSSEN SCIENCES IRELAND UC (IE) | 2019-04-16 | — | — | US | disclosed |
| US-10259814-B2 | Pyrrolo[3,2-d]pyrimidine derivatives for the treatment of viral infections and other diseases | JANSSEN SCIENCES IRELAND UC (IE) | 2019-04-16 | — | — | US | disclosed |
| US-20160168150-A1 | PYRROLO[3,2-D]PYRIMIDINE DERIVATIVES FOR THE TREATMENT OF VIRAL INFECTIONS AND OTHER DISEASES | JANSSEN SCIENCES IRELAND UC (IE) | 2016-06-16 | — | — | US | disclosed |
| US-20160168150-A1 | PYRROLO[3,2-D]PYRIMIDINE DERIVATIVES FOR THE TREATMENT OF VIRAL INFECTIONS AND OTHER DISEASES | JANSSEN SCIENCES IRELAND UC (IE) | 2016-06-16 | — | — | US | disclosed |
| US-20160168150-A1 | PYRROLO[3,2-D]PYRIMIDINE DERIVATIVES FOR THE TREATMENT OF VIRAL INFECTIONS AND OTHER DISEASES | JANSSEN SCIENCES IRELAND UC (IE) | 2016-06-16 | — | — | US | disclosed |
| US-20150239892-A1 | Pyrrolo[3,2-]pyrimidine derivatives for the treatment of viral infections and other diseases | JANSSEN R&D IRELAND (IE) | 2015-08-27 | — | — | US | disclosed |
| US-20150239892-A1 | Pyrrolo[3,2-]pyrimidine derivatives for the treatment of viral infections and other diseases | JANSSEN R&D IRELAND (IE) | 2015-08-27 | — | — | US | disclosed |
| US-20150239892-A1 | Pyrrolo[3,2-]pyrimidine derivatives for the treatment of viral infections and other diseases | JANSSEN R&D IRELAND (IE) | 2015-08-27 | — | — | US | disclosed |
| EP-2906563-A1 | PYRROLO[3,2-D]PYRIMIDINE DERIVATIVES FOR THE TREATMENT OF VIRAL INFECTIONS AND OTHER DISEASES | Janssen Sciences Ireland UC (IE) | 2015-08-19 | — | — | EP | disclosed |
| WO-2014207082-A1 | PYRROLO[3,2-D]PYRIMIDINE DERIVATIVES FOR THE TREATMENT OF VIRAL INFECTIONS AND OTHER DISEASES | JANSSEN R&D IRELAND (IE) | 2014-12-31 | — | — | WO | disclosed |
| WO-2014056953-A1 | PYRROLO[3,2-D]PYRIMIDINE DERIVATIVES FOR THE TREATMENT OF VIRAL INFECTIONS AND OTHER DISEASES | JANSSEN R&D IRELAND (IE) | 2014-04-17 | — | — | WO | disclosed |
| WO-2014056953-A1 | PYRROLO[3,2-D]PYRIMIDINE DERIVATIVES FOR THE TREATMENT OF VIRAL INFECTIONS AND OTHER DISEASES | JANSSEN R&D IRELAND (IE) | 2014-04-17 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (7 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10385054-B2 | Pyrrolo[3,2-d]pyrimidine derivatives for the treatment of viral infections and other diseases | TYMS, TYMP, DPYD | HTT 986/4885MEN1 4353/4885KMT2A 2677/4885 |
| US-11220504-B2 | Pyrrolo[3,2-d] pyrimidine derivatives for the treatment of viral infections and other diseases | TYMS, TYMP, DPYD | HTT 986/4885MEN1 4353/4885KMT2A 2677/4885 |
| US-20160168150-A1 | PYRROLO[3,2-D]PYRIMIDINE DERIVATIVES FOR THE TREATMENT OF VIRAL INFECTIONS AND OTHER DISEASES | TYMS, TYMP, DPYD | HTT 986/4885MEN1 4353/4885KMT2A 2677/4885 |
| US-20150239892-A1 | Pyrrolo[3,2-]pyrimidine derivatives for the treatment of viral infections and other diseases | TYMS, TYMP, DPYD | HTT 976/4885MEN1 4140/4885KMT2A 2719/4885 |
| US-10781216-B2 | Pyrrolo [3,2-d]pyrimidine derivatives for the treatment of viral infections and other diseases | TYMS, TYMP, DPYD | HTT 986/4885MEN1 4353/4885KMT2A 2677/4885 |
| US-10259814-B2 | Pyrrolo[3,2-d]pyrimidine derivatives for the treatment of viral infections and other diseases | TYMS, TYMP, DPYD | HTT 986/4885MEN1 4353/4885KMT2A 2677/4885 |
| US-20190330217-A1 | PYRROLO[3,2-D]PYRIMIDINE DERIVATIVES FOR THE TREATMENT OF VIRAL INFECTIONS AND OTHER DISEASES | TYMS, TYMP, DPYD | HTT 986/4885MEN1 4353/4885KMT2A 2677/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.