Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 3/20 | 0.55 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.55 |
| ▸ | HTT | P42858 | 1/20 | 0.55 |
| ▸ | ADORA3 | P0DMS8 | 2/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.46 |
| ▸ | GLA | P06280 | 1/20 | 0.46 |
| ▸ | POLB | P06746 | 1/20 | 0.46 |
| ▸ | ACHE | P22303 | 6/20 | 0.44 |
| ▸ | APP | P05067 | 4/20 | 0.44 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.41 |
| ▸ | HPGD | P15428 | 2/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.41 |
| ▸ | PKM | P14618 | 1/20 | 0.41 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.41 |
| ▸ | NPC1 | O15118 | 2/20 | 0.40 |
| ▸ | GAA | P10253 | 1/20 | 0.40 |
| ▸ | RAB9A | P51151 | 1/20 | 0.40 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4095003 | 0.74 | ACHE (0.43) | MEN1KMT2AADORA3KDM4EGLA | |
| SCHEMBL11156129 | 0.73 | MAPT (0.61) | MEN1KMT2AHTTADORA3KDM4E | |
| SCHEMBL16386438 | 0.73 | HTT (0.34) | MEN1KMT2AHTTADORA3HPGD | |
| SCHEMBL7244671 | 0.72 | ALDH1A1 (0.51) | MEN1KMT2AHTTADORA3KDM4E | |
| SCHEMBL17827896 | 0.71 | MAPT (0.55) | MEN1KMT2AKDM4EPOLBALOX15 | |
| SCHEMBL2910688 | 0.71 | LMNA (0.47) | MEN1KMT2AHTTKDM4EPOLB | |
| SCHEMBL13926372 | 0.71 | KMT2A (0.56) | MEN1KMT2AHTTKDM4EGLA | |
| SCHEMBL23711614 | 0.70 | PIK3C3 (0.40) | MEN1KMT2AHTTALDH1A1SMN1; SMN2 | |
| SCHEMBL15140307 | 0.68 | KDM4E (0.71) | MEN1KMT2AHTTKDM4EPOLB | |
| SCHEMBL20352579 | 0.67 | SMN1; SMN2 (0.47) | KDM4EGLAPOLBALOX15ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-105601619-A | JAK kinase modulating compounds and methods of use thereof | AMBIT BIOSCIENCES CORP | 2016-05-25 | — | — | CN | disclosed |
| CN-102395576-A | Quinazoline derivatives that modulate JAK kinases and methods of use thereof | AMBIT BIOSCIENCES CORP | 2012-03-28 | — | — | CN | disclosed |