Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HPGD | P15428 | 4/20 | 0.44 |
| ▸ | MAPK10 | P53779 | 3/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.44 |
| ▸ | MAPT | P10636 | 3/20 | 0.44 |
| ▸ | LMNA | P02545 | 2/20 | 0.44 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.44 |
| ▸ | ATM | Q13315 | 1/20 | 0.43 |
| ▸ | TSHR | P16473 | 1/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.41 |
| ▸ | MAPK8 | P45983 | 2/20 | 0.41 |
| ▸ | HTT | P42858 | 1/20 | 0.41 |
| ▸ | MAPK9 | P45984 | 1/20 | 0.41 |
| ▸ | PRNP | P04156 | 1/20 | 0.41 |
| ▸ | PPARG | P37231 | 1/20 | 0.41 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.41 |
| ▸ | NCOR2 | Q9Y618 | 1/20 | 0.41 |
| ▸ | RAB9A | P51151 | 1/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.39 |
| ▸ | NR3C1 | P04150 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1696067 | 0.86 | MAPK8 (0.51) | HPGDMAPK10ALDH1A1LMNANPSR1 | |
| SCHEMBL13657149 | 0.82 | LMNA (0.40) | HPGDMAPK10ALDH1A1MAPTLMNA | |
| SCHEMBL1696336 | 0.78 | L3MBTL1 (0.58) | HPGDMAPK10ALDH1A1MAPTLMNA | |
| SCHEMBL1637543 | 0.77 | ATM (0.47) | ALDH1A1MAPTNPSR1KDM4EATM | |
| SCHEMBL1696327 | 0.73 | MAPK8 (0.52) | MAPK10ALDH1A1NPSR1MAPK8PRNP | |
| SCHEMBL1696056 | 0.73 | L3MBTL1 (0.45) | HPGDMAPK10ALDH1A1MAPTLMNA | |
| SCHEMBL12073631 | 0.73 | L3MBTL1 (0.45) | HPGDMAPK10ALDH1A1MAPTLMNA | |
| SCHEMBL9298424 | 0.73 | ALDH1A1 (0.57) | ALDH1A1MAPTLMNANPSR1KDM4E | |
| SCHEMBL2485730 | 0.73 | ALDH1A1 (0.57) | ALDH1A1MAPTLMNANPSR1KDM4E | |
| SCHEMBL11697241 | 0.72 | ATM (0.56) | ALDH1A1NPSR1ATMTSHRRAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20110098483-A1 | Substituted Nitrogen Heterocycles and Synthesis and Uses Thereof | UNIVERSITY OF SOUTHERN CALIFORNIA (US) | 2011-04-28 | — | — | US | disclosed |
| US-20110098483-A1 | Substituted Nitrogen Heterocycles and Synthesis and Uses Thereof | UNIVERSITY OF SOUTHERN CALIFORNIA (US) | 2011-04-28 | — | — | US | disclosed |
| US-20110098483-A1 | Substituted Nitrogen Heterocycles and Synthesis and Uses Thereof | UNIVERSITY OF SOUTHERN CALIFORNIA (US) | 2011-04-28 | — | — | US | disclosed |
| WO-2009121033-A2 | SUBSTITUTED NITROGEN HETEROCYCLES AND SYNTHESIS AND USES THEREOF | UNIVERSITY OF SOUTHERN CALIFORNIA (US) | 2009-10-01 | — | — | WO | disclosed |
| US-20090247766-A1 | Substituted Nitrogen Heterocycles and Synthesis and Uses Thereof | UNIVERSITY OF SOUTHERN CALIFORNIA (US) | 2009-10-01 | — | — | US | disclosed |
| US-20090247766-A1 | Substituted Nitrogen Heterocycles and Synthesis and Uses Thereof | UNIVERSITY OF SOUTHERN CALIFORNIA (US) | 2009-10-01 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110098483-A1 | Substituted Nitrogen Heterocycles and Synthesis and Uses Thereof | PAH, NAT1, NNT | HPGD 42/4885MAPK10 1726/4885ALDH1A1 677/4885 |
| US-20090247766-A1 | Substituted Nitrogen Heterocycles and Synthesis and Uses Thereof | PAH, NAT1, NNT | HPGD 42/4885MAPK10 1726/4885ALDH1A1 677/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.