Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 2/20 | 0.50 |
| ▸ | AURKA | O14965 | 1/20 | 0.41 |
| ▸ | PARP1 | P09874 | 1/20 | 0.41 |
| ▸ | AXL | P30530 | 1/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.38 |
| ▸ | ERN1 | O75460 | 2/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | NPC1 | O15118 | 1/20 | 0.38 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.38 |
| ▸ | IDO1 | P14902 | 1/20 | 0.38 |
| ▸ | RAB9A | P51151 | 1/20 | 0.38 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.38 |
| ▸ | MET | P08581 | 2/20 | 0.37 |
| ▸ | GPR84 | Q9NQS5 | 1/20 | 0.37 |
| ▸ | FEN1 | P39748 | 1/20 | 0.37 |
| ▸ | TRIM24 | O15164 | 1/20 | 0.36 |
| ▸ | TRIM33 | Q9UPN9 | 1/20 | 0.36 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.35 |
| ▸ | MAP2K1 | Q02750 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29935587 | 1.00 | KMT2A (0.50) | KMT2AAURKAPARP1AXLKDM4E | |
| SCHEMBL12336934 | 0.79 | KMT2A (0.37) | KMT2AAURKAPARP1AXLKDM4E | |
| SCHEMBL10126734 | 0.77 | KMT2A (0.40) | KMT2AAURKAPARP1KDM4EMEN1 | |
| SCHEMBL4668018 | 0.76 | CAMKK2 (0.38) | KMT2AAURKAPARP1KDM4EFEN1 | |
| SCHEMBL4667699 | 0.76 | CAMKK2 (0.38) | KMT2AAURKAPARP1KDM4EFEN1 | |
| SCHEMBL4776889 | 0.74 | CCNC (0.42) | KMT2AAURKAAXLMEN1MET | |
| SCHEMBL4776882 | 0.74 | CCNC (0.42) | KMT2AAURKAAXLMEN1MET | |
| SCHEMBL30631993 | 0.72 | PDPK1 (0.48) | KMT2AAURKAPARP1AXLKDM4E | |
| SCHEMBL1495296 | 0.72 | PDPK1 (0.48) | KMT2AAURKAPARP1AXLKDM4E | |
| SCHEMBL174642 | 0.72 | PDPK1 (0.48) | KMT2AAURKAPARP1AXLKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 81 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-111620868-B | Preparation method of 1H-pyrazolo [3,4-b ] pyridine-3-formaldehyde | 爱斯特（成都）生物制药股份有限公司 | 2021-08-31 | — | — | CN | claimed |
| CN-111620868-A | Preparation method of 1H-pyrazolo [3,4-b ] pyridine-3-formaldehyde | 爱斯特（成都）生物制药股份有限公司 | 2020-09-04 | — | — | CN | claimed |
| CN-111848612-B | Compound containing fused heterocyclic structure, preparation method and application thereof, and bactericide | 华中师范大学 | 2021-09-14 | — | — | CN | disclosed |
| CN-111620868-B | Preparation method of 1H-pyrazolo [3,4-b ] pyridine-3-formaldehyde | 爱斯特（成都）生物制药股份有限公司 | 2021-08-31 | — | — | CN | disclosed |
| CN-111620868-B | Preparation method of 1H-pyrazolo [3,4-b ] pyridine-3-formaldehyde | 爱斯特（成都）生物制药股份有限公司 | 2021-08-31 | — | — | CN | disclosed |
| CN-111620868-B | Preparation method of 1H-pyrazolo [3,4-b ] pyridine-3-formaldehyde | 爱斯特（成都）生物制药股份有限公司 | 2021-08-31 | — | — | CN | disclosed |
| CN-111848612-A | Compound containing fused heterocyclic structure, preparation method and application thereof, and bactericide | 华中师范大学 | 2020-10-30 | — | — | CN | disclosed |
| CN-111620868-A | Preparation method of 1H-pyrazolo [3,4-b ] pyridine-3-formaldehyde | 爱斯特（成都）生物制药股份有限公司 | 2020-09-04 | — | — | CN | disclosed |
| CN-111620868-A | Preparation method of 1H-pyrazolo [3,4-b ] pyridine-3-formaldehyde | 爱斯特（成都）生物制药股份有限公司 | 2020-09-04 | — | — | CN | disclosed |
| CN-111620868-A | Preparation method of 1H-pyrazolo [3,4-b ] pyridine-3-formaldehyde | 爱斯特（成都）生物制药股份有限公司 | 2020-09-04 | — | — | CN | disclosed |
| EP-2155203-B1 | AZAINDAZOLE COMPOUNDS AND METHODS OF USE | CHEMOCENTRYX INC (US) | 2018-10-17 | — | — | EP | disclosed |
| WO-2008147815-A1 | 3-(IMIDAZOLYL)-PYRAZOLO[3,4-B]PYRIDINES | CHEMOCENTRYX, INC. (US) | 2008-12-04 | — | — | WO | disclosed |
| WO-2008147815-A1 | 3-(IMIDAZOLYL)-PYRAZOLO[3,4-B]PYRIDINES | CHEMOCENTRYX, INC. (US) | 2008-12-04 | — | — | WO | disclosed |
| US-20080300257-A1 | 3-(IMIDAZOLYL)-PYRAZOLO[3,4-b]PYRIDINES | CHEMOCENTRYX, INC. (US) | 2008-12-04 | — | — | US | disclosed |
| US-20080300257-A1 | 3-(IMIDAZOLYL)-PYRAZOLO[3,4-b]PYRIDINES | CHEMOCENTRYX, INC. (US) | 2008-12-04 | — | — | US | disclosed |
| US-20080300257-A1 | 3-(IMIDAZOLYL)-PYRAZOLO[3,4-b]PYRIDINES | CHEMOCENTRYX, INC. (US) | 2008-12-04 | — | — | US | disclosed |
| WO-2008147822-A1 | AZAINDAZOLE COMPOUNDS AND METHODS OF USE | CHEMOCENTRYX, INC. (US) | 2008-12-04 | — | — | WO | disclosed |
| US-20080058341-A1 | AZAINDAZOLE COMPOUNDS AND METHODS OF USE | CHEMOCENTRYX, INC. | 2008-03-06 | — | — | US | disclosed |
| US-20080058341-A1 | AZAINDAZOLE COMPOUNDS AND METHODS OF USE | CHEMOCENTRYX, INC. | 2008-03-06 | — | — | US | disclosed |
| US-20080058341-A1 | AZAINDAZOLE COMPOUNDS AND METHODS OF USE | CHEMOCENTRYX, INC. | 2008-03-06 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080058341-A1 | AZAINDAZOLE COMPOUNDS AND METHODS OF USE | CCR1, CCR3, CCR4 | KMT2A 3304/4885AURKA 4036/4885PARP1 2306/4885 |
| US-20080300257-A1 | 3-(IMIDAZOLYL)-PYRAZOLO[3,4-b]PYRIDINES | CCR1, CCR3, CCR4 | KMT2A 4763/4885AURKA 3274/4885PARP1 2691/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.