Sugi Predict

Sugi Predict / Compounds / SCHEMBL174642

SCHEMBL174642

SCHEMBL174642

Nc1n[nH]c2ncccc12

nearest known ligand 0.48

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ PDPK1 O15530 2/20 0.48
▸ KDM4E B2RXH2 2/20 0.48
▸ CYP3A4 P08684 1/20 0.48
▸ GAA P10253 1/20 0.48
▸ TGFBR1 P36897 1/20 0.44
▸ AXL P30530 2/20 0.42
▸ CHEK1 O14757 1/20 0.42
▸ FLT3 P36888 1/20 0.42
▸ PLK3 Q9H4B4 1/20 0.42
▸ TBK1 Q9UHD2 1/20 0.41
▸ AURKA O14965 1/20 0.41
▸ PARP1 P09874 1/20 0.41
▸ GPR84 Q9NQS5 1/20 0.41
▸ CDK5 Q00535 2/20 0.40
▸ NOS3 P29474 2/20 0.40
▸ NOS1 P29475 2/20 0.40
▸ NOS2 P35228 2/20 0.40
▸ CCNT1 O60563 1/20 0.40
▸ CCNA2 P20248 1/20 0.40
▸ CDK2 P24941 1/20 0.40

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL1495296 1.00 PDPK1 (0.48) PDPK1KDM4ECYP3A4GAATGFBR1
SCHEMBL30631993 1.00 PDPK1 (0.48) PDPK1KDM4ECYP3A4GAATGFBR1
SCHEMBL3638218 0.77 CAMKK2 (0.36) PDPK1KDM4ECYP3A4GAATGFBR1
SCHEMBL30884587 0.77 CAMKK2 (0.36) PDPK1KDM4ECYP3A4GAATGFBR1
SCHEMBL1343940 0.77 GPR84 (0.44) PDPK1KDM4ETGFBR1AXLAURKA
SCHEMBL174792 0.77 AXL (0.41) KDM4ECYP3A4AXLAURKAPARP1
SCHEMBL253764 0.77 NPC1 (0.43) KDM4EAXLAURKAPARP1GPR84
SCHEMBL1593049 0.77 AXL (0.50) KDM4EAXLAURKAPARP1GPR84
SCHEMBL1573790 0.77 AXL (0.41) KDM4ECYP3A4AXLAURKAPARP1
SCHEMBL1639471 0.77 AXL (0.41) KDM4ETGFBR1AXLAURKAPARP1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 189 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-116874541-B Plant growth regulator and preparation method thereof 潍坊市阳光化工股份有限公司 2024-02-20 — — CN claimed
CN-116874541-A Plant growth regulator and preparation method thereof 潍坊市阳光化工股份有限公司 2023-10-13 — — CN claimed
US-12630549-B2 Pyrazoleamide derivatives HOFFMANN-LA ROCHE INC. (US) 2026-05-19 — — US disclosed
EP-4703350-A1 METHOD FOR PREPARING 4-AMINOINDAN AND METHOD FOR PREPARING DIHYDROINDENYL-PYRAZOLO[3,4-B]PYRIDINE-AMINE JW Pharmaceutical Corporation (KR) 2026-03-04 — — EP disclosed
EP-4703351-A1 METHOD OF PREPARING 4-AMINOINDAN AND METHOD OF PREPARING DIHYDROINDENYL-PYRAZOLO[3,4-B]PYRIDINE-AMINE COMPOUND JW Pharmaceutical Corporation (KR) 2026-03-04 — — EP disclosed
EP-3996710-B1 INHIBITOR OF MAP KINASE INTERACTING SERINE/THREONINE KINASE 1 (MNK1) AND MAP KINASE INTERACTING SERINE/THREONINE KINASE 2 (MNK2), CANCER THERAPY AND THERAPEUTIC COMBINATIONS FUNDACIO HOSPITAL UNIV VALL DHEBRON INSTITUT DE RECERCA (ES) 2025-01-22 — — EP disclosed
WO-2024224297-A1 METHOD FOR PREPARING 4-AMINOINDAN AND METHOD FOR PREPARING DIHYDROINDENYL-PYRAZOLO[3,4-B]PYRIDINE-AMINE 제이더블유중외제약 주식회사 2024-10-31 — — WO disclosed
WO-2024224297-A1 METHOD FOR PREPARING 4-AMINOINDAN AND METHOD FOR PREPARING DIHYDROINDENYL-PYRAZOLO[3,4-B]PYRIDINE-AMINE 제이더블유중외제약 주식회사 2024-10-31 — — WO disclosed
WO-2024224298-A1 METHOD OF PREPARING 4-AMINOINDAN AND METHOD OF PREPARING DIHYDROINDENYL-PYRAZOLO[3,4-B]PYRIDINE-AMINE COMPOUND 제이더블유중외제약 주식회사 2024-10-31 — — WO disclosed
WO-2024224298-A1 METHOD OF PREPARING 4-AMINOINDAN AND METHOD OF PREPARING DIHYDROINDENYL-PYRAZOLO[3,4-B]PYRIDINE-AMINE COMPOUND 제이더블유중외제약 주식회사 2024-10-31 — — WO disclosed
US-20240216316-A1 DIHOMO-GAMMA LINOLENIC ACID (DGLA) IS A NOVEL SENOLYTIC BUCK INST RES AGING (US) 2024-07-04 — — US disclosed
US-20040039007-A1 Compositions useful as inhibitors of GSK-3 VERTEX PHARMACEUTICALS INCORPORATED 2004-02-26 — — US disclosed
WO-2004013140-A1 PYRAZOLE COMPOSITIONS USEFUL AS INHIBITORS OF GSK-3 VERTEX PHARMACEUTICALS INCORPORATED (US) 2004-02-12 — — WO disclosed
US-4366231-A Photographic material containing a stabilizer, a process for its production, a development process, new pyrazoles, a process for their production and intermediate products AGFA GEVAERT AKTIENGESELLSCHAFT (DE) 1982-12-28 — — US disclosed
US-4361568-A 5-(Pyridinyl)-1H-pyrazolo[3,4-b]pyridin-3-amines and their cardiotonic use STERLING DRUG INC. (US) 1982-11-30 — — US disclosed
US-4264603-A 5-(Pyridinyl)-1H-pyrazolo[3,4-b]pyridine-3-amines, their use as cardiotonics and their preparation STERLING DRUG INC. (US) 1981-04-28 — — US disclosed
US-4260621-A ANTICOAGULANTS BOEHRINGER INGELHEIM GMBH (DE) 1981-04-07 — — US disclosed
US-4224322-A ANTICOAGULANTS, ANTIPHLOGISTICS BOEHRINGER INGELHEIM GMBH (DE) 1980-09-23 — — US disclosed
US-4182887-A ANTIPHLOGISTIC, ANTITHROMBOTIC BOEHRINGER INGELHEIM GMBH (DE) 1980-01-08 — — US disclosed
US-3872133-A 3-AMINO-1H-PYRAZOLO(3,4-B)PYRIDINES HOECHST AG 1975-03-18 — — US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20240216316-A1 DIHOMO-GAMMA LINOLENIC ACID (DGLA) IS A NOVEL SENOLYTIC DAGLA, DAGLB, MGLL PDPK1 2032/4885KDM4E 3408/4885CYP3A4 4330/4885
US-20040039007-A1 Compositions useful as inhibitors of GSK-3 GSK3A, GSK3B, GSKIP PDPK1 39/4885KDM4E 1288/4885CYP3A4 3356/4885
US-12630549-B2 Pyrazoleamide derivatives CYP11B2, CYP11B1, ADRA1B PDPK1 888/4885KDM4E 3127/4885CYP3A4 27/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.

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