Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 5/20 | 0.59 |
| ▸ | HSD17B10 | Q99714 | 5/20 | 0.59 |
| ▸ | ESR1 | P03372 | 6/20 | 0.57 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.57 |
| ▸ | ADORA3 | P0DMS8 | 2/20 | 0.57 |
| ▸ | ATM | Q13315 | 2/20 | 0.57 |
| ▸ | PGR | P06401 | 2/20 | 0.57 |
| ▸ | AR | P10275 | 2/20 | 0.57 |
| ▸ | SLC6A3 | Q01959 | 2/20 | 0.57 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.57 |
| ▸ | TBXA2R | P21731 | 1/20 | 0.57 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.57 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.57 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.56 |
| ▸ | ABCC4 | O15439 | 2/20 | 0.55 |
| ▸ | ABCC1 | P33527 | 1/20 | 0.55 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.55 |
| ▸ | STS | P08842 | 3/20 | 0.54 |
| ▸ | MAPT | P10636 | 4/20 | 0.54 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.54 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2610024 | 1.00 | LMNA (0.59) | LMNAHSD17B10ESR1SMN1; SMN2ADORA3 | |
| SCHEMBL16393331 | 0.90 | HSD17B10 (0.74) | LMNAHSD17B10ESR1SMN1; SMN2ADORA3 | |
| SCHEMBL5155673 | 0.90 | HSD17B10 (0.74) | LMNAHSD17B10ESR1SMN1; SMN2ADORA3 | |
| SCHEMBL14026325 | 0.90 | HSD17B10 (0.74) | LMNAHSD17B10ESR1SMN1; SMN2ADORA3 | |
| SCHEMBL795948 | 0.88 | LMNA (0.57) | LMNAHSD17B10ESR1SMN1; SMN2ADORA3 | |
| SCHEMBL14026326 | 0.88 | LMNA (0.57) | LMNAHSD17B10ESR1SMN1; SMN2ADORA3 | |
| SCHEMBL17808696 | 0.85 | LMNA (0.60) | LMNAHSD17B10ESR1SMN1; SMN2ADORA3 | |
| SCHEMBL17121947 | 0.85 | LMNA (0.53) | LMNAHSD17B10ESR1SMN1; SMN2ADORA3 | |
| SCHEMBL10079788 | 0.84 | LMNA (0.77) | LMNAHSD17B10ESR1SMN1; SMN2ADORA3 | |
| SCHEMBL13015302 | 0.84 | LMNA (0.77) | LMNAHSD17B10ESR1SMN1; SMN2ADORA3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2015006691-A1 | PRO-DRUG FORMING COMPOUNDS | EVESTRA, INC. (US) | 2015-01-15 | — | — | WO | disclosed |