SCHEMBL16396332

SCHEMBL16396332

Fc1cc(Br)c(Cl)cc1CBr

nearest known ligand 0.40

Predicted protein targets (top 4)

geneUniProtsupporting neighboursconfidence
AHR P35869 2/20 0.37
CSNK2A1 P68400 3/20 0.34
KDM1A O60341 2/20 0.31
KDM1B Q8NB78 2/20 0.31

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL30758646 1.00 AHR (0.37) AHRCSNK2A1KDM1AKDM1B
SCHEMBL3365678 0.83 GPR84 (0.35) KDM1AKDM1B
SCHEMBL693457 0.82 GPR84 (0.37) KDM1AKDM1B
SCHEMBL31266184 0.82 GPR84 (0.37) KDM1AKDM1B
SCHEMBL11027502 0.80 GPR84 (0.36) KDM1AKDM1B
SCHEMBL377065 0.79 KDM1A (0.41) KDM1AKDM1B
SCHEMBL29545980 0.79 KDM1A (0.41) KDM1AKDM1B
SCHEMBL377235 0.77 KDM1A (0.39) KDM1AKDM1B
SCHEMBL30474348 0.77 KDM1A (0.39) KDM1AKDM1B
SCHEMBL1759465 0.76 AHR (0.46) AHRCSNK2A1KDM1AKDM1B

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20240239816-A1 BORONO-PHENYLALANINE DERIVATIVE STELLA PHARMA CORPORATION (JP) 2024-07-18 US disclosed
EP-4361159-A1 BORONO-PHENYLALANINE DERIVATIVE Stella Pharma Corporation (JP) 2024-05-01 EP disclosed
CN-117545759-A Derivatives of dihydroxyborylphenylalanine 斯特拉制药公司 2024-02-09 CN disclosed
WO-2022270143-A1 BORONO-PHENYLALANINE DERIVATIVE ステラファーマ株式会社 2022-12-29 WO disclosed
US-10562912-B2 Heterocyclic derivatives and use thereof C&C RESEARCH LABORATORIES (KR) 2020-02-18 US disclosed
EP-3004057-B1 HETEROCYCLIC DERIVATIVES AND THEIR USE AS STAT 3 INHIBITORS C&C RES LAB (KR) 2018-07-25 EP disclosed
US-20160108056-A1 HETEROCYCLIC DERIVATIVES AND USE THEREOF C&C RESEARCH LABORATORIES (KR) 2016-04-21 US disclosed
EP-3004057-A1 HETEROCYCLIC DERIVATIVES AND USE THEREOF C&C Research Laboratories (KR) 2016-04-13 EP disclosed
WO-2014196793-A1 HETEROCYCLIC DERIVATIVES AND USE THEREOF C&C RESEARCH LABORATORIES (KR) 2014-12-11 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20240239816-A1 BORONO-PHENYLALANINE DERIVATIVE SLC7A1, SLC1A5, LATS2 AHR 798/4885CSNK2A1 1012/4885KDM1A 2483/4885
US-20160108056-A1 HETEROCYCLIC DERIVATIVES AND USE THEREOF STAT3, JAK2, STAT5A AHR 2073/4885CSNK2A1 18/4885KDM1A 3433/4885
US-10562912-B2 Heterocyclic derivatives and use thereof STAT3, JAK2, STAT5A AHR 2073/4885CSNK2A1 18/4885KDM1A 3433/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.