Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | STK17B | O94768 | 1/20 | 0.43 |
| ▸ | RET | P07949 | 1/20 | 0.42 |
| ▸ | KDR | P35968 | 1/20 | 0.42 |
| ▸ | ADORA3 | P0DMS8 | 3/20 | 0.40 |
| ▸ | MAOB | P27338 | 2/20 | 0.40 |
| ▸ | CYP19A1 | P11511 | 2/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.40 |
| ▸ | AR | P10275 | 2/20 | 0.40 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.40 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
| ▸ | CASP6 | P55212 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.39 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.39 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.39 |
| ▸ | MAPT | P10636 | 3/20 | 0.37 |
| ▸ | HTT | P42858 | 2/20 | 0.37 |
| ▸ | HBB | P68871 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.36 |
| ▸ | NPC1 | O15118 | 2/20 | 0.36 |
| ▸ | RAB9A | P51151 | 2/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1892218 | 0.81 | RET (0.51) | STK17BRETKDRADORA3MAOB | |
| SCHEMBL9837501 | 0.81 | RET (0.41) | STK17BRETKDRADORA3MAOB | |
| SCHEMBL7840884 | 0.78 | RET (0.38) | STK17BRETKDRADORA3MAOB | |
| SCHEMBL29155508 | 0.77 | POLB (0.43) | MAOBPOLBCASP6LMNA | |
| SCHEMBL1431562 | 0.77 | RET (0.49) | STK17BRETKDRADORA3MAOB | |
| SCHEMBL28472788 | 0.75 | RET (0.40) | STK17BRETKDRADORA3MAOB | |
| SCHEMBL10974720 | 0.75 | POLB (0.47) | KDM4EPOLBCASP6SMN1; SMN2HTT | |
| SCHEMBL10974722 | 0.75 | POLB (0.47) | KDM4EPOLBCASP6SMN1; SMN2HTT | |
| SCHEMBL4224331 | 0.72 | MAPT (0.52) | RETKDRMAOBCYP19A1KDM4E | |
| SCHEMBL10852658 | 0.70 | CYP19A1 (0.40) | STK17BRETKDRADORA3MAOB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3004073-A1 | 3-CARBOXY SUBSTITUTED COUMARIN DERIVATIVES WITH A POTENTIAL UTILITY FOR THE TREATMENT OF CANCER DISEASES | Université catholique de Louvain (BE) | 2016-04-13 | — | — | EP | disclosed |
| WO-2014195507-A1 | 3-CARBOXY SUBSTITUTED COUMARIN DERIVATIVES WITH A POTENTIAL UTILITY FOR THE TREATMENT OF CANCER DISEASES | UNIVERSITE CATHOLIQUE DE LOUVAIN (BE) | 2014-12-11 | — | — | WO | disclosed |