Sugi Predict

Sugi Predict / Compounds / SCHEMBL1892218

SCHEMBL1892218

SCHEMBL1892218

O=C(O)C1C(=O)c2ccccc2OC1c1ccccc1

nearest known ligand 0.51

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ RET P07949 1/20 0.51
▸ KDR P35968 1/20 0.51
▸ ADORA3 P0DMS8 3/20 0.46
▸ MAOB P27338 3/20 0.46
▸ CYP19A1 P11511 2/20 0.46
▸ AR P10275 2/20 0.46
▸ KDM4E B2RXH2 1/20 0.46
▸ HSD17B10 Q99714 1/20 0.46
▸ CYP3A4 P08684 3/20 0.43
▸ ALOX15 P16050 1/20 0.43
▸ MAPT P10636 2/20 0.41
▸ MAPK1 P28482 2/20 0.41
▸ NPC1 O15118 1/20 0.41
▸ RAB9A P51151 1/20 0.41
▸ DNMT3B Q9UBC3 1/20 0.40
▸ LMNA P02545 1/20 0.40
▸ TP53 P04637 1/20 0.40
▸ CYP1A2 P05177 1/20 0.40
▸ HTR2B P41595 1/20 0.40
▸ STK17B O94768 1/20 0.39

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL4224331 0.86 MAPT (0.52) RETKDRMAOBCYP19A1AR
SCHEMBL27614200 0.84 RET (0.47) RETKDRADORA3MAOBCYP19A1
SCHEMBL16397347 0.81 STK17B (0.43) RETKDRADORA3MAOBCYP19A1
SCHEMBL28472788 0.80 RET (0.40) RETKDRADORA3MAOBCYP19A1
SCHEMBL1886532 0.80 CYP3A4 (0.45) RETKDRADORA3MAOBCYP19A1
SCHEMBL1886531 0.80 CYP3A4 (0.45) RETKDRADORA3MAOBCYP19A1
SCHEMBL28902155 0.80 TSHR (0.52) RETKDRCYP3A4ALOX15MAPT
SCHEMBL24115843 0.79 RET (0.77) RETKDRADORA3MAOBCYP19A1
SCHEMBL3362960 0.79 RET (0.77) RETKDRADORA3MAOBCYP19A1
SCHEMBL29843330 0.79 RET (0.77) RETKDRADORA3MAOBCYP19A1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-116837007-A Phyllostachys Pubescens flavonoid compound synthesis related gene PnF H and application thereof 浙江农林大学 2023-10-03 — — CN disclosed
CN-111718912-A Flavanone-3-hydroxylase antigen epitope peptide, antibody and application thereof 华中农业大学 2020-09-29 — — CN disclosed
US-20110117649-A1 Catalytic enantioselective synthesis of flavanones and chromanones NATIONAL INSTITUTES OF HEALTH - DIRECTOR DEITR 2011-05-19 — — US disclosed
US-7851640-B2 Catalytic enantioselective synthesis of flavanones and chromanones NORTHWESTERN UNIVERSITY (US) 2010-12-14 — — US disclosed
US-20090259055-A1 Catalytic enantioselective synthesis of flavanones and chromanones NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT 2009-10-15 — — US disclosed
WO-2009108392-A2 CATALYTIC ENANTIOSELECTIVE SYNTHESIS OF FLAVANONES AND CHROMANES NORTHWESTERN UNIVERSITY (US) 2009-09-03 — — WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20090259055-A1 Catalytic enantioselective synthesis of flavanones and chromanones RNGTT, CDK20, TBXAS1 RET 3774/4885KDR 2511/4885ADORA3 1130/4885
US-20110117649-A1 Catalytic enantioselective synthesis of flavanones and chromanones RNGTT, CDK20, TBXAS1 RET 3774/4885KDR 2511/4885ADORA3 1130/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.