SCHEMBL16397646

SCHEMBL16397646

O=C(O)C1=COc2ccccc2C1.O=C(O)C1=COc2ccccc2C1

nearest known ligand 0.42

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
MAOA P21397 2/20 0.42
MAOB P27338 2/20 0.42
ALDH1A1 P00352 3/20 0.36
KDM4E B2RXH2 2/20 0.36
HSD17B10 Q99714 2/20 0.36
GAA P10253 1/20 0.36
HPGD P15428 1/20 0.36
MAPK1 P28482 1/20 0.36
NOTUM Q6P988 1/20 0.36
SRD5A2 P31213 2/20 0.35
ACSL1 P33121 1/20 0.33
HDAC4 P56524 1/20 0.33
HDAC7 Q8WUI4 1/20 0.33
HDAC5 Q9UQL6 1/20 0.33
OXTR P30559 1/20 0.32
DAO P14920 1/20 0.32
TSHR P16473 1/20 0.32
NAPRT Q6XQN6 1/20 0.32
ALOX15 P16050 1/20 0.32
ALPL P05186 1/20 0.32

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL212723 1.00 MAOA (0.42) MAOAMAOBALDH1A1KDM4EHSD17B10
SCHEMBL2230058 0.84 MAOA (0.41) MAOAMAOBALDH1A1KDM4EHSD17B10
SCHEMBL9058873 0.84 MAOA (0.41) MAOAMAOBALDH1A1KDM4EGAA
Trifluoroacetic Acid SCHEMBL16669664 0.78 MAOA (0.33) MAOAMAOBALDH1A1KDM4EHSD17B10
SCHEMBL4539282 0.76 MAOA (0.41) MAOAMAOBOXTR
SCHEMBL6818277 0.76 SRD5A1 (0.41) ALDH1A1NOTUMSRD5A2TSHRALOX15
SCHEMBL4537383 0.76 TSHR (0.45) ALDH1A1KDM4EHSD17B10GAAHPGD
SCHEMBL29351770 0.76 TSHR (0.45) ALDH1A1KDM4EHSD17B10GAAHPGD
SCHEMBL8665717 0.74 AKR1B1 (0.38) MAOAMAOBKDM4EGAAHPGD
SCHEMBL2708309 0.74 MAOA (0.38) MAOAMAOBALDH1A1KDM4EHSD17B10

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-3004073-A1 3-CARBOXY SUBSTITUTED COUMARIN DERIVATIVES WITH A POTENTIAL UTILITY FOR THE TREATMENT OF CANCER DISEASES Université catholique de Louvain (BE) 2016-04-13 EP disclosed
WO-2014195507-A1 3-CARBOXY SUBSTITUTED COUMARIN DERIVATIVES WITH A POTENTIAL UTILITY FOR THE TREATMENT OF CANCER DISEASES UNIVERSITE CATHOLIQUE DE LOUVAIN (BE) 2014-12-11 WO disclosed