SCHEMBL6818277

SCHEMBL6818277

O=C(O)C1=COc2ccc(Cl)cc2C1

nearest known ligand 0.41

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
SRD5A1 P18405 3/20 0.41
SRD5A2 P31213 3/20 0.41
HSP90AA1 P07900 1/20 0.39
NOTUM Q6P988 1/20 0.39
TSHR P16473 2/20 0.37
ALDH1A1 P00352 1/20 0.37
TP53 P04637 1/20 0.37
CASP1 P29466 1/20 0.37
SMN1; SMN2 Q16637 1/20 0.37
AHR P35869 3/20 0.37
CA2 P00918 2/20 0.36
CA1 P00915 1/20 0.36
CA12 O43570 1/20 0.35
CA9 Q16790 1/20 0.35
KMO O15229 1/20 0.35
PTGS1 P23219 1/20 0.35
PTGS2 P35354 1/20 0.35
POLB P06746 1/20 0.35
ALOX15 P16050 1/20 0.33
GRIK1 P39086 1/20 0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL6821138 0.89 AHR (0.38) SRD5A1SRD5A2HSP90AA1NOTUMAHR
SCHEMBL13692384 0.86 NOTUM (0.38) SRD5A1SRD5A2HSP90AA1NOTUMALDH1A1
SCHEMBL13689265 0.82 CA12 (0.35) SRD5A1SRD5A2NOTUMTSHRALDH1A1
SCHEMBL13687525 0.81 MEN1 (0.38) SRD5A1SRD5A2HSP90AA1NOTUMALDH1A1
SCHEMBL212723 0.76 MAOA (0.42) SRD5A1SRD5A2NOTUMTSHRALDH1A1
SCHEMBL16397646 0.76 MAOA (0.42) SRD5A1SRD5A2NOTUMTSHRALDH1A1
SCHEMBL14267965 0.73 AHR (0.38) ALDH1A1TP53AHRALOX15CMA1
SCHEMBL8626958 0.72 AHR (0.38) AHRCMA1HTT
SCHEMBL11809222 0.69 POLB (0.46) SRD5A1SRD5A2HSP90AA1NOTUMKMO
SCHEMBL14864585 0.68 NOTUM (0.36) NOTUMTSHRALDH1A1SMN1; SMN2CA12

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2004046122-A2 BENZOXAZOLE, BENZTHIAZOLE AND BENZIMIDAZOLE ACID DERIVATIVES AND THEIR USE AS HEPARANASE INHIBITORS OXFORD GLYCOSCIENCES (UK) LTD (GB) 2004-06-03 WO disclosed