Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.36 |
| ▸ | HTT | P42858 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.36 |
| ▸ | RAB9A | P51151 | 3/20 | 0.36 |
| ▸ | JAK3 | P52333 | 1/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.32 |
| ▸ | SRD5A2 | P31213 | 1/20 | 0.32 |
| ▸ | HCAR2 | Q8TDS4 | 1/20 | 0.31 |
| ▸ | NPC1 | O15118 | 1/20 | 0.31 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11896867 | 0.84 | SMN1; SMN2 (0.33) | SMN1; SMN2HTTRAB9ANPC1HRH3 | |
| SCHEMBL19886319 | 0.69 | NPC1 (0.49) | SMN1; SMN2KMT2ARAB9AALDH1A1NPC1 | |
| SCHEMBL19691216 | 0.69 | SMYD3 (0.42) | SMN1; SMN2KMT2ARAB9ANPC1 | |
| SCHEMBL28631654 | 0.68 | KMT2A (0.46) | SMN1; SMN2HTTKMT2ATDP1RAB9A | |
| SCHEMBL9426831 | 0.67 | — | — | |
| SCHEMBL30149273 | 0.67 | KDM4E (0.36) | TDP1ALDH1A1HCAR2 | |
| SCHEMBL30522334 | 0.67 | — | — | |
| SCHEMBL28905564 | 0.67 | — | — | |
| SCHEMBL15555122 | 0.67 | KMT2A (0.44) | SMN1; SMN2HTTKMT2ATDP1RAB9A | |
| SCHEMBL22372184 | 0.66 | HIF1A (0.45) | TDP1ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 11 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3626242-B1 | ITRACONAZOLE ANALOGS AS INHIBITORS OF FIBROSIS | SCRIPPS RESEARCH INST (US) | 2024-08-07 | — | — | EP | disclosed |
| EP-3626242-A1 | ITRACONAZOLE ANALOGS AS INHIBITORS OF FIBROSIS | The Scripps Research Institute (US) | 2020-03-25 | — | — | EP | disclosed |
| EP-3003038-B1 | 2H-1,2,3-TRIAZOLE DERIVATIVES AS INHIBITORS OF FIBROSIS | SCRIPPS RESEARCH INST (US) | 2019-08-14 | — | — | EP | disclosed |
| CN-105392364-B | Small molecule inhibitors of fibrosis | 加州生物医学研究所 | 2018-09-14 | — | — | CN | disclosed |
| US-9981956-B2 | Small molecule inhibitors of fibrosis | THE SCRIPPS RESEARCH INSTITUTE (US) | 2018-05-29 | — | — | US | disclosed |
| US-20170217943-A1 | SMALL MOLECULE INHIBITORS OF FIBROSIS | THE SCRIPPS RESEARCH INSTITUTE | 2017-08-03 | — | — | US | disclosed |
| US-9663499-B2 | Small molecule inhibitors of fibrosis | THE CALIFORNIA INSTITUTE FOR BIOMEDICAL RESEARCH (US) | 2017-05-30 | — | — | US | disclosed |
| US-20160130258-A1 | SMALL MOLECULE INHIBITORS OF FIBROSIS | THE SCRIPPS RESEARCH INSTITUTE | 2016-05-12 | — | — | US | disclosed |
| EP-3003038-A1 | SMALL MOLECULE INHIBITORS OF FIBROSIS | The California Institute for Biomedical Research (US) | 2016-04-13 | — | — | EP | disclosed |
| CN-105392364-A | Small molecule inhibitors of fibrosis | CALIFORNIA INST BIOMEDICAL RES | 2016-03-09 | — | — | CN | disclosed |
| WO-2014197738-A1 | SMALL MOLECULE INHIBITORS OF FIBROSIS | THE CALIFORNIA INSTITUTE FOR BIOMEDICAL RESEARCH (US) | 2014-12-11 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20160130258-A1 | SMALL MOLECULE INHIBITORS OF FIBROSIS | MMP1, COL2A1, MMP8 | SMN1; SMN2 4073/4885HTT 4637/4885KMT2A 4178/4885 |
| US-20170217943-A1 | SMALL MOLECULE INHIBITORS OF FIBROSIS | MMP1, COL2A1, MMP8 | SMN1; SMN2 4073/4885HTT 4637/4885KMT2A 4178/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.