Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP1A2 | P05177 | 3/20 | 0.59 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.59 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.59 |
| ▸ | POLB | P06746 | 2/20 | 0.59 |
| ▸ | GPR3 | P46089 | 1/20 | 0.50 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.48 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.48 |
| ▸ | MAPT | P10636 | 2/20 | 0.40 |
| ▸ | NPC1 | O15118 | 1/20 | 0.39 |
| ▸ | RAB9A | P51151 | 1/20 | 0.39 |
| ▸ | GLA | P06280 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | RAD52 | P43351 | 1/20 | 0.38 |
| ▸ | NR1I3 | Q14994 | 2/20 | 0.37 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.37 |
| ▸ | VDR | P11473 | 1/20 | 0.37 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.37 |
| ▸ | CYP2B6 | P20813 | 1/20 | 0.37 |
| ▸ | AHR | P35869 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25863814 | 0.80 | ALDH1A1 (0.59) | CYP1A2ALDH1A1CYP2C19POLBGPR3 | |
| SCHEMBL29450270 | 0.76 | POLB (0.70) | CYP1A2ALDH1A1CYP2C19POLBGPR3 | |
| SCHEMBL9694998 | 0.76 | POLB (0.70) | CYP1A2ALDH1A1CYP2C19POLBGPR3 | |
| SCHEMBL2724218 | 0.75 | ALDH1A1 (1.00) | CYP1A2ALDH1A1CYP2C19POLBKDM4E | |
| SCHEMBL3461366 | 0.75 | KDM4E (0.44) | CYP1A2ALDH1A1CYP2C19POLBGPR3 | |
| SCHEMBL1640925 | 0.74 | POLB (0.52) | CYP1A2ALDH1A1CYP2C19POLBGPR3 | |
| SCHEMBL1408391 | 0.74 | POLB (1.00) | ALDH1A1POLBGPR3KDM4ESMN1; SMN2 | |
| SCHEMBL29395416 | 0.73 | CYP1A2 (0.61) | CYP1A2ALDH1A1CYP2C19POLBGPR3 | |
| SCHEMBL4272933 | 0.73 | POLB (0.66) | CYP1A2ALDH1A1CYP2C19POLBGPR3 | |
| SCHEMBL25863813 | 0.73 | ALDH1A1 (0.50) | CYP1A2ALDH1A1CYP2C19POLBGPR3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012052556-A1 | NOVEL HALOALKOXYQUINAZOLINES, AND PREPARATION AND USE THEREOF | UNIVERSITÄT LEIPZIG (DE) | 2012-04-26 | — | — | WO | disclosed |
| US-20110190272-A1 | CHEMICAL COMPOUNDS | ASTRAZENECA AB (SE) | 2011-08-04 | — | — | US | disclosed |
| US-20110098283-A1 | 3-CINNOLINECARBOXAMIDE DERIVATIVES AND THEIR USE FOR TREATING CANCER | ASTRAZENECA AB | 2011-04-28 | — | — | US | disclosed |
| US-7723337-B2 | 3-cinnolinecarboxamide derivatives and their use for treating cancer | ASTRAZENECA AB (SE) | 2010-05-25 | — | — | US | disclosed |
| US-20090012084-A1 | 3-CINNOLINECARBOXAMIDE DERIVATIVES AND THEIR USE FOR TREATING CANCER | ASTRAZENECA AB (SE) | 2009-01-08 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110190272-A1 | CHEMICAL COMPOUNDS | CSF3R, FLT3, CILK1 | CYP1A2 4470/4885ALDH1A1 1561/4885CYP2C19 4226/4885 |
| US-20110098283-A1 | 3-CINNOLINECARBOXAMIDE DERIVATIVES AND THEIR USE FOR TREATING CANCER | CSF3R, CSF1R, KIT | CYP1A2 3403/4885ALDH1A1 538/4885CYP2C19 2694/4885 |
| US-20090012084-A1 | 3-CINNOLINECARBOXAMIDE DERIVATIVES AND THEIR USE FOR TREATING CANCER | CSF3R, CSF1R, KIT | CYP1A2 3403/4885ALDH1A1 538/4885CYP2C19 2694/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.