Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.44 |
| ▸ | POLB | P06746 | 2/20 | 0.44 |
| ▸ | PKM | P14618 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.37 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.37 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 3/20 | 0.35 |
| ▸ | HPGD | P15428 | 1/20 | 0.35 |
| ▸ | RAD52 | P43351 | 1/20 | 0.34 |
| ▸ | HTT | P42858 | 2/20 | 0.34 |
| ▸ | LMNA | P02545 | 1/20 | 0.34 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.34 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.34 |
| ▸ | TLR8 | Q9NR97 | 1/20 | 0.33 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.33 |
| ▸ | VDR | P11473 | 1/20 | 0.33 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.33 |
| ▸ | CYP2B6 | P20813 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3461322 | 0.77 | CYP1A2 (0.41) | KDM4EPOLBALDH1A1CYP1A2CYP2C19 | |
| SCHEMBL1640068 | 0.75 | CYP1A2 (0.59) | KDM4EPOLBALDH1A1CYP1A2CYP2C19 | |
| SCHEMBL3463166 | 0.70 | KDM4E (0.54) | KDM4EPOLBALDH1A1CYP1A2CYP2C19 | |
| SCHEMBL3071109 | 0.67 | ALDH1A1 (0.50) | KDM4EPOLBALDH1A1CYP1A2KMT2A | |
| SCHEMBL12737723 | 0.66 | KDM4E (0.50) | KDM4EALDH1A1CYP1A2KMT2AMAPT | |
| SCHEMBL3063629 | 0.66 | KDM4E (0.48) | KDM4EPOLBALDH1A1CYP1A2KMT2A | |
| SCHEMBL1408391 | 0.64 | POLB (1.00) | KDM4EPOLBALDH1A1SMN1; SMN2KMT2A | |
| SCHEMBL18045058 | 0.63 | CYSLTR1 (0.55) | CYP1A2TLR8 | |
| SCHEMBL8161366 | 0.63 | KDM4E (0.46) | KDM4EPOLBALDH1A1CYP1A2KMT2A | |
| SCHEMBL19952669 | 0.63 | KDM4E (0.46) | KDM4EPOLBALDH1A1CYP1A2CYP2C19 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7723337-B2 | 3-cinnolinecarboxamide derivatives and their use for treating cancer | ASTRAZENECA AB (SE) | 2010-05-25 | — | — | US | disclosed |
| US-20090012084-A1 | 3-CINNOLINECARBOXAMIDE DERIVATIVES AND THEIR USE FOR TREATING CANCER | ASTRAZENECA AB (SE) | 2009-01-08 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090012084-A1 | 3-CINNOLINECARBOXAMIDE DERIVATIVES AND THEIR USE FOR TREATING CANCER | CSF3R, CSF1R, KIT | KDM4E 2188/4885POLB 3777/4885PKM 2976/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.