Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 3/20 | 0.52 |
| ▸ | GPR3 | P46089 | 1/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.42 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.42 |
| ▸ | IMPDH2 | P12268 | 1/20 | 0.39 |
| ▸ | IMPDH1 | P20839 | 1/20 | 0.39 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.38 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.38 |
| ▸ | RAD52 | P43351 | 1/20 | 0.35 |
| ▸ | GLA | P06280 | 1/20 | 0.34 |
| ▸ | MAPT | P10636 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.34 |
| ▸ | CASP1 | P29466 | 1/20 | 0.34 |
| ▸ | CASP14 | P31944 | 1/20 | 0.34 |
| ▸ | CASP3 | P42574 | 1/20 | 0.34 |
| ▸ | CASP2 | P42575 | 1/20 | 0.34 |
| ▸ | CASP4 | P49662 | 1/20 | 0.34 |
| ▸ | CASP5 | P51878 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23942265 | 0.77 | GPR3 (0.48) | POLBGPR3KDM4EALDH1A1CYP1A2 | |
| SCHEMBL1640068 | 0.74 | CYP1A2 (0.59) | POLBGPR3KDM4EALDH1A1MAPK1 | |
| SCHEMBL20301264 | 0.73 | KDM4E (0.48) | POLBGPR3KDM4EALDH1A1SMN1; SMN2 | |
| SCHEMBL14289088 | 0.72 | GPR3 (0.43) | POLBGPR3KDM4EALDH1A1CYP1A2 | |
| SCHEMBL15160141 | 0.71 | ALDH1A1 (0.67) | POLBKDM4EALDH1A1MAPK1SMN1; SMN2 | |
| SCHEMBL20178365 | 0.71 | LRRK2 (0.54) | POLBIMPDH2IMPDH1EGFR | |
| SCHEMBL7830291 | 0.71 | POLB (0.59) | POLBKDM4EALDH1A1MAPK1SMN1; SMN2 | |
| SCHEMBL31636814 | 0.69 | POLB (0.56) | POLBKDM4EALDH1A1CYP1A2SQOR | |
| SCHEMBL1408391 | 0.69 | POLB (1.00) | POLBGPR3KDM4EALDH1A1MAPK1 | |
| SCHEMBL31171419 | 0.67 | KDM4E (0.61) | POLBKDM4EALDH1A1MAPK1SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20110190272-A1 | CHEMICAL COMPOUNDS | ASTRAZENECA AB (SE) | 2011-08-04 | — | — | US | disclosed |
| US-20110098283-A1 | 3-CINNOLINECARBOXAMIDE DERIVATIVES AND THEIR USE FOR TREATING CANCER | ASTRAZENECA AB | 2011-04-28 | — | — | US | disclosed |
| US-7723337-B2 | 3-cinnolinecarboxamide derivatives and their use for treating cancer | ASTRAZENECA AB (SE) | 2010-05-25 | — | — | US | disclosed |
| US-20090012084-A1 | 3-CINNOLINECARBOXAMIDE DERIVATIVES AND THEIR USE FOR TREATING CANCER | ASTRAZENECA AB (SE) | 2009-01-08 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110190272-A1 | CHEMICAL COMPOUNDS | CSF3R, FLT3, CILK1 | POLB 3154/4885GPR3 1801/4885KDM4E 2870/4885 |
| US-20110098283-A1 | 3-CINNOLINECARBOXAMIDE DERIVATIVES AND THEIR USE FOR TREATING CANCER | CSF3R, CSF1R, KIT | POLB 3777/4885GPR3 64/4885KDM4E 2188/4885 |
| US-20090012084-A1 | 3-CINNOLINECARBOXAMIDE DERIVATIVES AND THEIR USE FOR TREATING CANCER | CSF3R, CSF1R, KIT | POLB 3777/4885GPR3 64/4885KDM4E 2188/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.