Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 9/20 | 0.51 |
| ▸ | RAB9A | P51151 | 6/20 | 0.51 |
| ▸ | MEN1 | O00255 | 5/20 | 0.51 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.51 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.51 |
| ▸ | GAA | P10253 | 2/20 | 0.50 |
| ▸ | EIF4E | P06730 | 2/20 | 0.48 |
| ▸ | PTPRF | P10586 | 1/20 | 0.47 |
| ▸ | PTPN2 | P17706 | 1/20 | 0.47 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.47 |
| ▸ | LMNA | P02545 | 3/20 | 0.46 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.46 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.46 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.46 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.46 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.46 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.46 |
| ▸ | HTT | P42858 | 1/20 | 0.46 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14150266 | 0.89 | EIF4E (0.52) | MAPTRAB9AMEN1KMT2AGAA | |
| SCHEMBL16404001 | 0.87 | EIF4E (0.57) | MAPTRAB9AMEN1KMT2AMAPK1 | |
| SCHEMBL16404021 | 0.86 | THRB (0.47) | MAPTMEN1KMT2AEIF4E | |
| SCHEMBL14306164 | 0.85 | EIF4E (0.49) | MAPTRAB9AMEN1KMT2AMAPK1 | |
| SCHEMBL14318314 | 0.85 | EIF4E (0.49) | EIF4E | |
| SCHEMBL27721951 | 0.81 | MEN1 (0.53) | MAPTMEN1KMT2AMAPK1GAA | |
| SCHEMBL16404162 | 0.81 | ATP4A (0.55) | MAPTRAB9AMEN1KMT2AMAPK1 | |
| SCHEMBL16404000 | 0.78 | NAMPT (0.46) | MAPTMEN1KMT2AMAPK1SMN1; SMN2 | |
| SCHEMBL14318315 | 0.78 | EIF4E (0.40) | RAB9AMEN1KMT2AEIF4ESMN1; SMN2 | |
| SCHEMBL14482063 | 0.77 | RAB9A (0.75) | MAPTRAB9AMEN1KMT2AMAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2718290-B1 | COMPOSITIONS AND METHODS FOR MODULATING A KINASE | CLEVEXEL PHARMA (FR) | 2016-05-04 | — | — | EP | disclosed |
| EP-2718290-B1 | COMPOSITIONS AND METHODS FOR MODULATING A KINASE | CLEVEXEL PHARMA (FR) | 2016-05-04 | — | — | EP | disclosed |
| US-8937065-B2 | Compositions and methods for modulating a kinase | CLEVEXEL PHARMA (FR) | 2015-01-20 | — | — | US | disclosed |
| US-8937065-B2 | Compositions and methods for modulating a kinase | CLEVEXEL PHARMA (FR) | 2015-01-20 | — | — | US | disclosed |