Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CCNC | P24863 | 1/20 | 0.55 |
| ▸ | CDK8 | P49336 | 1/20 | 0.55 |
| ▸ | TGFBR1 | P36897 | 1/20 | 0.46 |
| ▸ | RAB9A | P51151 | 4/20 | 0.44 |
| ▸ | GAA | P10253 | 3/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.44 |
| ▸ | POLB | P06746 | 2/20 | 0.44 |
| ▸ | HTT | P42858 | 1/20 | 0.44 |
| ▸ | RECQL | P46063 | 3/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.43 |
| ▸ | HPGD | P15428 | 2/20 | 0.43 |
| ▸ | MAPT | P10636 | 2/20 | 0.43 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.43 |
| ▸ | TSHR | P16473 | 1/20 | 0.42 |
| ▸ | NPC1 | O15118 | 3/20 | 0.42 |
| ▸ | PKM | P14618 | 1/20 | 0.42 |
| ▸ | TRIM24 | O15164 | 1/20 | 0.41 |
| ▸ | CASP3 | P42574 | 1/20 | 0.40 |
| ▸ | CASP2 | P42575 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16403981 | 0.83 | RAB9A (0.43) | RAB9AGAAKDM4EPOLBHTT | |
| SCHEMBL16403980 | 0.83 | KDM4E (0.44) | RAB9AGAAKDM4EPOLBHTT | |
| SCHEMBL14315445 | 0.81 | NPC1 (0.56) | RAB9AKDM4EPOLBALDH1A1HPGD | |
| SCHEMBL16403932 | 0.80 | ALDH1A1 (0.45) | RAB9AGAAKDM4EPOLBHTT | |
| SCHEMBL16403985 | 0.80 | RAB9A (0.41) | RAB9AGAAKDM4EPOLBHTT | |
| SCHEMBL14224988 | 0.79 | RAB9A (0.41) | RAB9AGAAKDM4EPOLBHTT | |
| SCHEMBL16403992 | 0.79 | RAB9A (0.60) | RAB9AGAAKDM4EPOLBHTT | |
| SCHEMBL14325854 | 0.79 | NPC1 (0.53) | RAB9AGAAKDM4EPOLBALDH1A1 | |
| SCHEMBL16403922 | 0.78 | KDM4E (0.61) | RAB9AGAAKDM4EPOLBHTT | |
| SCHEMBL16403964 | 0.78 | KDM4E (0.49) | RAB9AGAAKDM4EPOLBHTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8937065-B2 | Compositions and methods for modulating a kinase | CLEVEXEL PHARMA (FR) | 2015-01-20 | — | — | US | disclosed |