Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 6/20 | 0.52 |
| ▸ | LMNA | P02545 | 2/20 | 0.52 |
| ▸ | THRB | P10828 | 1/20 | 0.51 |
| ▸ | TP53 | P04637 | 1/20 | 0.49 |
| ▸ | GRM4 | Q14833 | 1/20 | 0.48 |
| ▸ | RAB9A | P51151 | 5/20 | 0.48 |
| ▸ | MEN1 | O00255 | 3/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.48 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.47 |
| ▸ | GLA | P06280 | 1/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.44 |
| ▸ | MAPT | P10636 | 5/20 | 0.43 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.43 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.43 |
| ▸ | RELA | Q04206 | 1/20 | 0.43 |
| ▸ | HPGD | P15428 | 1/20 | 0.43 |
| ▸ | MAOB | P27338 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16404158 | 0.91 | NPC1 (0.50) | NPC1TP53RAB9AMEN1KMT2A | |
| SCHEMBL16403943 | 0.89 | RAB9A (0.47) | NPC1LMNATP53RAB9AMEN1 | |
| SCHEMBL16403962 | 0.88 | NPC1 (0.49) | NPC1LMNATP53GRM4RAB9A | |
| SCHEMBL16403951 | 0.88 | RAB9A (0.47) | NPC1TP53RAB9AMEN1KMT2A | |
| SCHEMBL16404120 | 0.85 | NPC1 (0.63) | NPC1LMNATHRBTP53MEN1 | |
| SCHEMBL14325852 | 0.85 | NPC1 (0.66) | NPC1LMNATP53RAB9AMEN1 | |
| SCHEMBL16403936 | 0.85 | ALDH1A1 (0.51) | NPC1LMNARAB9AMEN1KMT2A | |
| SCHEMBL14317616 | 0.85 | NPC1 (0.52) | NPC1TP53RAB9AMEN1KMT2A | |
| SCHEMBL16403952 | 0.83 | NPC1 (0.57) | NPC1LMNATHRBTP53RAB9A | |
| SCHEMBL14315443 | 0.82 | RAB9A (0.63) | NPC1LMNATP53RAB9AMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8937065-B2 | Compositions and methods for modulating a kinase | CLEVEXEL PHARMA (FR) | 2015-01-20 | — | — | US | disclosed |