Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTT | P42858 | 2/20 | 0.56 |
| ▸ | LMNA | P02545 | 2/20 | 0.56 |
| ▸ | KMT2A | Q03164 | 6/20 | 0.55 |
| ▸ | NPC1 | O15118 | 6/20 | 0.55 |
| ▸ | RAB9A | P51151 | 6/20 | 0.55 |
| ▸ | MEN1 | O00255 | 5/20 | 0.55 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.55 |
| ▸ | MAPT | P10636 | 5/20 | 0.54 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.53 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.53 |
| ▸ | POLB | P06746 | 2/20 | 0.53 |
| ▸ | NFKB1 | P19838 | 2/20 | 0.53 |
| ▸ | NFKB2 | Q00653 | 2/20 | 0.53 |
| ▸ | RELA | Q04206 | 2/20 | 0.53 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.53 |
| ▸ | PAX8 | Q06710 | 1/20 | 0.52 |
| ▸ | TP53 | P04637 | 2/20 | 0.50 |
| ▸ | BRD4 | O60885 | 1/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.49 |
| ▸ | HPGD | P15428 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14318379 | 0.85 | LMNA (0.53) | HTTLMNAKMT2ANPC1RAB9A | |
| SCHEMBL16404131 | 0.83 | NPC1 (0.54) | HTTLMNAKMT2ANPC1RAB9A | |
| SCHEMBL16404109 | 0.82 | NPC1 (0.49) | LMNAKMT2ANPC1RAB9AMEN1 | |
| SCHEMBL14318277 | 0.81 | MAPT (0.54) | HTTLMNAKMT2ANPC1RAB9A | |
| SCHEMBL16404095 | 0.81 | NPC1 (0.57) | KMT2ANPC1RAB9AMEN1L3MBTL1 | |
| SCHEMBL16404099 | 0.79 | GRM5 (0.48) | KMT2ANPC1RAB9AMEN1MAPT | |
| SCHEMBL12519402 | 0.78 | HTT (0.66) | HTTLMNAKMT2ANPC1RAB9A | |
| SCHEMBL16404094 | 0.78 | RAB9A (0.54) | LMNAKMT2ANPC1RAB9AMEN1 | |
| SCHEMBL2533808 | 0.78 | THRB (0.65) | LMNAKMT2ANPC1RAB9AMEN1 | |
| SCHEMBL12519404 | 0.78 | HTT (0.64) | HTTLMNAKMT2ANPC1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8937065-B2 | Compositions and methods for modulating a kinase | CLEVEXEL PHARMA (FR) | 2015-01-20 | — | — | US | disclosed |