Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SYK | P43405 | 3/20 | 0.41 |
| ▸ | MAPT | P10636 | 3/20 | 0.39 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.39 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.38 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.38 |
| ▸ | RAF1 | P04049 | 1/20 | 0.38 |
| ▸ | BRAF | P15056 | 1/20 | 0.38 |
| ▸ | DRD2 | P14416 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.37 |
| ▸ | LMNA | P02545 | 2/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.37 |
| ▸ | MCOLN3 | Q8TDD5 | 1/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.37 |
| ▸ | ALDH3A1 | P30838 | 1/20 | 0.37 |
| ▸ | ALDH1A3 | P47895 | 1/20 | 0.37 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.37 |
| ▸ | NSD2 | O96028 | 1/20 | 0.37 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.37 |
| ▸ | LGMN | Q99538 | 1/20 | 0.36 |
| ▸ | GAA | P10253 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3753099 | 0.82 | CCR5 (0.47) | SYKMAPTCYP2C9SMN1; SMN2LMNA | |
| SCHEMBL519730 | 0.82 | MAPT (0.54) | SYKMAPTRAF1BRAFSMN1; SMN2 | |
| SCHEMBL2627227 | 0.77 | HTT (0.57) | MAPTCYP2C9SMN1; SMN2LMNAALDH1A1 | |
| SCHEMBL19496762 | 0.74 | ALDH1A1 (0.51) | MAPTALOX15HSD17B10SMN1; SMN2LMNA | |
| SCHEMBL17290434 | 0.73 | DRD2 (0.38) | SYKMAPTCYP2C9ALOX15HSD17B10 | |
| SCHEMBL15652359 | 0.73 | MAPT (0.58) | SYKMAPTSMN1; SMN2LMNAALDH1A1 | |
| SCHEMBL17083367 | 0.72 | ALDH1A1 (0.48) | MAPTSMN1; SMN2LMNAALDH1A1MCOLN3 | |
| SCHEMBL15298889 | 0.71 | SMN1; SMN2 (0.50) | ALOX15HSD17B10SMN1; SMN2ALDH1A1KDM4E | |
| SCHEMBL24195919 | 0.71 | ALDH1A1 (0.42) | MAPTSMN1; SMN2LMNAALDH1A1KDM4E | |
| SCHEMBL13826326 | 0.70 | SMN1; SMN2 (0.64) | MAPTCYP2C9SMN1; SMN2LMNAALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2200436-B1 | SUBSTITUTED PYRIMIDINYL-AMINES AS PROTEIN KINASE INHIBITORS | SCRIPPS RESEARCH INST (US) | 2015-01-21 | — | — | EP | disclosed |