Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 7/20 | 0.55 |
| ▸ | LMNA | P02545 | 2/20 | 0.55 |
| ▸ | GSTM2 | P28161 | 1/20 | 0.54 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.53 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.52 |
| ▸ | ALPG | P10696 | 1/20 | 0.52 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.50 |
| ▸ | AKR1B10 | O60218 | 1/20 | 0.50 |
| ▸ | AKR1B1 | P15121 | 1/20 | 0.50 |
| ▸ | AKR1C4 | P17516 | 1/20 | 0.50 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.50 |
| ▸ | AKR1C2 | P52895 | 1/20 | 0.50 |
| ▸ | AKR1C1 | Q04828 | 1/20 | 0.50 |
| ▸ | KAT2B | Q92831 | 1/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.48 |
| ▸ | MEN1 | O00255 | 2/20 | 0.48 |
| ▸ | NPC1 | O15118 | 1/20 | 0.48 |
| ▸ | GAA | P10253 | 1/20 | 0.48 |
| ▸ | RAB9A | P51151 | 1/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10580319 | 0.91 | MAPT (0.58) | MAPTLMNASMN1; SMN2TDP1ALPG | |
| SCHEMBL2220740 | 0.85 | MAPT (0.59) | MAPTLMNASMN1; SMN2TDP1ALPG | |
| SCHEMBL762553 | 0.85 | SMN1; SMN2 (0.60) | MAPTLMNASMN1; SMN2TDP1ALPG | |
| SCHEMBL6938256 | 0.84 | MEN1 (0.55) | MAPTLMNASMN1; SMN2ALDH1A1AKR1C3 | |
| SCHEMBL739095 | 0.84 | MAPT (0.64) | MAPTLMNASMN1; SMN2TDP1ALPG | |
| SCHEMBL24492393 | 0.84 | GSTM2 (0.51) | MAPTGSTM2ALDH1A1KAT2BNPC1 | |
| SCHEMBL27039041 | 0.83 | SMN1; SMN2 (0.55) | MAPTLMNASMN1; SMN2TDP1ALPG | |
| SCHEMBL30712055 | 0.83 | SMN1; SMN2 (0.55) | MAPTLMNASMN1; SMN2TDP1ALPG | |
| Hydrochloric Acid SCHEMBL9760520 | 0.83 | SMN1; SMN2 (0.55) | MAPTLMNASMN1; SMN2TDP1ALPG | |
| SCHEMBL10576590 | 0.82 | LMNA (0.68) | MAPTLMNASMN1; SMN2TDP1ALPG |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9328131-B2 | Benzimidazolium compounds | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2016-05-03 | — | — | US | disclosed |
| US-9073954-B2 | 5-substituted benzimidazolium compounds | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2015-07-07 | — | — | US | disclosed |
| WO-2015007519-A1 | NOVEL BENZIMIDAZOLIUM COMPOUNDS | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2015-01-22 | — | — | WO | disclosed |