Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH3 | Q9Y5N1 | 12/20 | 0.58 |
| ▸ | HPGD | P15428 | 1/20 | 0.49 |
| ▸ | PHGDH | O43175 | 4/20 | 0.47 |
| ▸ | NPC1 | O15118 | 2/20 | 0.45 |
| ▸ | RAB9A | P51151 | 2/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.45 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.44 |
| ▸ | TP53 | P04637 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31735384 | 0.83 | MEN1 (0.57) | HRH3HPGDSMN1; SMN2 | |
| SCHEMBL1372655 | 0.81 | HRH3 (0.54) | HRH3 | |
| SCHEMBL11397967 | 0.81 | HRH3 (0.54) | HRH3RAB9ASMN1; SMN2 | |
| SCHEMBL11142730 | 0.80 | KMT2A (0.53) | HRH3RAB9ASMN1; SMN2 | |
| SCHEMBL3089686 | 0.77 | HRH3 (0.54) | HRH3 | |
| SCHEMBL11144982 | 0.77 | HRH3 (0.54) | HRH3 | |
| SCHEMBL2629322 | 0.77 | KMT2A (0.60) | HPGDNPC1RAB9ASMN1; SMN2CHEK1 | |
| SCHEMBL28029422 | 0.77 | HRH3 (0.61) | HRH3PHGDH | |
| SCHEMBL27851621 | 0.76 | PHGDH (0.47) | HPGDPHGDHNPC1RAB9ASMN1; SMN2 | |
| SCHEMBL17185576 | 0.76 | HRH3 (0.44) | HRH3HPGDNPC1RAB9ASMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 11 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2025245484-A1 | FOXN1 ACTIVATORS | THYMOFOX INC. (US) | 2025-11-27 | — | — | WO | disclosed |
| WO-2025245461-A1 | METHODS OF ACTIVATING FOXN1 | THYMOFOX INC. (US) | 2025-11-27 | — | — | WO | disclosed |
| EP-2328586-A2 | SUBSTITUTED PYRIDAZINONE DERIVATIVES AS HISTAMINE-3 (H3) RECEPTOR LIGANDS | Cephalon, Inc. (US) | 2011-06-08 | — | — | EP | disclosed |
| US-20110098269-A1 | Substituted Pyridazinone Derivatives as Histamine-3 (H3) Receptor Ligands | CEPHALON, INC. (US) | 2011-04-28 | — | — | US | disclosed |
| WO-2009142732-A2 | SUBSTITUTED PYRIDAZINONE DERIVATIVES AS HISTAMINE-3 (H3) RECEPTOR LIGANDS | CEPHALON, INC. (US) | 2009-11-26 | — | — | WO | disclosed |
| US-7419979-B2 | Derivatives of 6-{4-[4-(1H-indole-2-sulphonyl)-piperazin-1-carbonyl-phenyl]}pyradizin-3-one | ASTRAZENECA AB (SE) | 2008-09-02 | — | — | US | disclosed |
| US-20070135441-A1 | New derivatives of 6-{4-[4-(1h-indole-2-sulphonyl)-piperazin-1-carbonyl-phenyl]}pyradizin-3-one | ASTRAZENECA AB (SE) | 2007-06-14 | — | — | US | disclosed |
| CN-1905883-A | Novel derivatives of 6- { 4- [ 4- (1H-indole-2-sulfonyl) -piperazine-1-carbonyl-phenyl ] } pyridazin-3-one | ASTRAZENECA AB (SE) | 2007-01-31 | — | — | CN | disclosed |
| WO-2007008145-A1 | HETEROCYCLIC SULFONAMIDE DERIVATIVES AS INHIBITORS OF FACTOR XA | ASTRAZENECA AB (SE) | 2007-01-18 | — | — | WO | disclosed |
| EP-1706120-A1 | NEW DERIVATIVES OF 6- 4 4 - 1 H - INDOLE-2-SULPHONYL)-PIPERA ZIN-1-CARBONYL-PHENYL PYRADIZIN-3-ONE | AstraZeneca AB (SE) | 2006-10-04 | — | — | EP | disclosed |
| WO-2005065688-A1 | NEW DERIVATIVES OF 6-4{4-[1H-INDOLE-2-SULPHONYL)-PIPERAZIN-1-CARBONYL-PHENYL]}PYRADIZIN-3-ONE | ASTRAZENECA AB (SE) | 2005-07-21 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110098269-A1 | Substituted Pyridazinone Derivatives as Histamine-3 (H3) Receptor Ligands | HRH3, HRH4, HRH2 | HRH3 1/4885HPGD 643/4885PHGDH 1596/4885 |
| US-20070135441-A1 | New derivatives of 6-{4-[4-(1h-indole-2-sulphonyl)-piperazin-1-carbonyl-phenyl]}pyradizin-3-one | HTR7, TRPC7, HRH4 | HRH3 22/4885HPGD 1639/4885PHGDH 4784/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.