Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LOXL2 | Q9Y4K0 | 1/20 | 0.33 |
| ▸ | ACAT2 | Q9BWD1 | 1/20 | 0.33 |
| ▸ | KDM1A | O60341 | 1/20 | 0.33 |
| ▸ | MAOA | P21397 | 1/20 | 0.33 |
| ▸ | MAOB | P27338 | 1/20 | 0.33 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.31 |
| ▸ | TSHR | P16473 | 1/20 | 0.31 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.31 |
| ▸ | USP2 | O75604 | 1/20 | 0.31 |
| ▸ | CTSC | P53634 | 1/20 | 0.30 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.30 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17757856 | 0.89 | KDM4E (0.35) | LOXL2ACAT2KDM1AMAOAMAOB | |
| SCHEMBL16410739 | 0.88 | KMT2A (0.39) | ACAT2TSHRSMN1; SMN2KMT2A | |
| SCHEMBL16410622 | 0.86 | KMT2A (0.37) | ACAT2KMT2A | |
| SCHEMBL16410867 | 0.82 | ALDH1A1 (0.34) | ACAT2TSHRSMN1; SMN2KMT2A | |
| SCHEMBL16410616 | 0.81 | ACAT2 (0.39) | ACAT2 | |
| SCHEMBL16410790 | 0.81 | LMNA (0.36) | ACAT2KMT2A | |
| SCHEMBL17757727 | 0.81 | USP2 (0.37) | LOXL2ACAT2KDM1AMAOAMAOB | |
| SCHEMBL16410608 | 0.81 | HRH3 (0.36) | ACAT2KDM1AMAOAMAOBCYP2D6 | |
| SCHEMBL16410742 | 0.79 | CA12 (0.33) | ACAT2 | |
| SCHEMBL17757083 | 0.79 | KDM4E (0.34) | LOXL2KDM1AMAOAMAOBCYP2D6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2015007730-A1 | SPIROQUINOXALINE DERIVATIVES AS INHIBITORS OF NON-APOPTOTIC REGULATED CELL-DEATH | Helmholtz Zentrum München - Deutsches Forschungszentrum für Gesundheit und Umwelt (GmbH) (DE) | 2015-01-22 | — | — | WO | disclosed |