Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACAT2 | Q9BWD1 | 2/20 | 0.36 |
| ▸ | SIGMAR1 | Q99720 | 10/20 | 0.34 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.33 |
| ▸ | FAAH | O00519 | 1/20 | 0.32 |
| ▸ | MEN1 | O00255 | 1/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.32 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.32 |
| ▸ | TSHR | P16473 | 1/20 | 0.32 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.32 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.32 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.32 |
| ▸ | ESR1 | P03372 | 1/20 | 0.31 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16410668 | 0.97 | ACAT2 (0.34) | ACAT2SIGMAR1MEN1ALDH1A1CYP2C9 | |
| SCHEMBL17757485 | 0.89 | ACAT2 (0.37) | ACAT2SIGMAR1L3MBTL1FAAHESR1 | |
| SCHEMBL16410623 | 0.87 | SSTR3 (0.36) | ACAT2SIGMAR1MEN1KMT2A | |
| SCHEMBL17757514 | 0.85 | HPGD (0.38) | ACAT2SIGMAR1MEN1TSHRCYP2C19 | |
| SCHEMBL16410721 | 0.85 | SIGMAR1 (0.33) | SIGMAR1MEN1ALDH1A1KMT2A | |
| SCHEMBL17757500 | 0.83 | ACAT2 (0.37) | ACAT2L3MBTL1MEN1ALDH1A1CYP2C9 | |
| SCHEMBL16410765 | 0.80 | ACAT2 (0.47) | ACAT2MEN1KMT2A | |
| SCHEMBL16410722 | 0.80 | OGA (0.32) | MEN1ALDH1A1CYP2C9TSHRCYP2C19 | |
| SCHEMBL17757652 | 0.79 | SIGMAR1 (0.36) | SIGMAR1L3MBTL1KMT2A | |
| SCHEMBL17757203 | 0.78 | ACAT2 (0.38) | ACAT2MEN1ALDH1A1CYP2C9TSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2015007730-A1 | SPIROQUINOXALINE DERIVATIVES AS INHIBITORS OF NON-APOPTOTIC REGULATED CELL-DEATH | Helmholtz Zentrum München - Deutsches Forschungszentrum für Gesundheit und Umwelt (GmbH) (DE) | 2015-01-22 | — | — | WO | disclosed |