Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SIGMAR1 | Q99720 | 3/20 | 0.33 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.32 |
| ▸ | MMP3 | P08254 | 1/20 | 0.32 |
| ▸ | LMNA | P02545 | 1/20 | 0.31 |
| ▸ | SSTR3 | P32745 | 1/20 | 0.31 |
| ▸ | HPGD | P15428 | 1/20 | 0.31 |
| ▸ | MEN1 | O00255 | 2/20 | 0.31 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.31 |
| ▸ | NPY1R | P25929 | 1/20 | 0.30 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.30 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16410623 | 0.89 | SSTR3 (0.36) | SIGMAR1EPHX2SSTR3HPGDMEN1 | |
| SCHEMBL17757096 | 0.89 | HPGD (0.37) | SIGMAR1EPHX2MMP3LMNAHPGD | |
| SCHEMBL16410668 | 0.88 | ACAT2 (0.34) | SIGMAR1EPHX2SSTR3HPGDMEN1 | |
| SCHEMBL16410778 | 0.86 | LMNA (0.38) | LMNA | |
| SCHEMBL16410809 | 0.86 | ACAT2 (0.35) | — | |
| SCHEMBL16410719 | 0.85 | ACAT2 (0.36) | SIGMAR1MEN1KMT2AALDH1A1 | |
| SCHEMBL17757411 | 0.84 | ALDH1A1 (0.40) | EPHX2MMP3LMNAMEN1KMT2A | |
| SCHEMBL16410834 | 0.82 | ACAT2 (0.36) | MEN1KMT2A | |
| SCHEMBL16410722 | 0.80 | OGA (0.32) | LMNAMEN1KMT2AALDH1A1 | |
| SCHEMBL17757846 | 0.79 | LMNA (0.39) | MMP3LMNAKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2015007730-A1 | SPIROQUINOXALINE DERIVATIVES AS INHIBITORS OF NON-APOPTOTIC REGULATED CELL-DEATH | Helmholtz Zentrum München - Deutsches Forschungszentrum für Gesundheit und Umwelt (GmbH) (DE) | 2015-01-22 | — | — | WO | disclosed |