Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | PDE7A | Q13946 | 3/20 | 0.34 |
| ▸ | PDE7B | Q9NP56 | 3/20 | 0.32 |
| ▸ | PDE5A | O76074 | 1/20 | 0.32 |
| ▸ | PDE4A | P27815 | 1/20 | 0.32 |
| ▸ | PDE1A | P54750 | 1/20 | 0.32 |
| ▸ | PDE1B | Q01064 | 1/20 | 0.32 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.32 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.32 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.32 |
| ▸ | PDE1C | Q14123 | 1/20 | 0.32 |
| ▸ | ACAT2 | Q9BWD1 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16410700 | 0.90 | ACAT2 (0.38) | KMT2AACAT2 | |
| SCHEMBL16410785 | 0.89 | PIK3CB (0.31) | — | |
| SCHEMBL16410758 | 0.89 | KMT2A (0.36) | KMT2APDE7AACAT2 | |
| SCHEMBL17757638 | 0.89 | KMT2A (0.40) | KMT2APDE7APDE7BPDE5APDE4A | |
| SCHEMBL17757626 | 0.89 | KMT2A (0.40) | KMT2APDE7APDE7BPDE5APDE4A | |
| SCHEMBL17757643 | 0.89 | KMT2A (0.40) | KMT2APDE7APDE7BPDE5APDE4A | |
| SCHEMBL16410739 | 0.85 | KMT2A (0.39) | KMT2APDE7AACAT2 | |
| SCHEMBL16410624 | 0.84 | SMN1; SMN2 (0.38) | KMT2A | |
| SCHEMBL16410622 | 0.83 | KMT2A (0.37) | KMT2APDE7AACAT2 | |
| SCHEMBL16410790 | 0.83 | LMNA (0.36) | KMT2APDE7AACAT2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2015007730-A1 | SPIROQUINOXALINE DERIVATIVES AS INHIBITORS OF NON-APOPTOTIC REGULATED CELL-DEATH | Helmholtz Zentrum München - Deutsches Forschungszentrum für Gesundheit und Umwelt (GmbH) (DE) | 2015-01-22 | — | — | WO | disclosed |