Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TAAR1 | Q96RJ0 | 3/20 | 0.40 |
| ▸ | MAPT | P10636 | 2/20 | 0.32 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.32 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.32 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.32 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.32 |
| ▸ | LMNA | P02545 | 1/20 | 0.32 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.32 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.32 |
| ▸ | GPR84 | Q9NQS5 | 1/20 | 0.32 |
| ▸ | MEN1 | O00255 | 1/20 | 0.32 |
| ▸ | NPC1 | O15118 | 1/20 | 0.32 |
| ▸ | RAB9A | P51151 | 1/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.32 |
| ▸ | SLC26A6 | Q9BXS9 | 1/20 | 0.31 |
| ▸ | PLAAT3 | P53816 | 1/20 | 0.31 |
| ▸ | PLAAT5 | Q96KN8 | 1/20 | 0.31 |
| ▸ | PLAAT2 | Q9NWW9 | 1/20 | 0.31 |
| ▸ | PLAAT4 | Q9UL19 | 1/20 | 0.31 |
| ▸ | HIF1A | Q16665 | 2/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16410854 | 0.93 | TAAR1 (0.35) | TAAR1MAPTLMNATDP1KDM4E | |
| SCHEMBL16410765 | 0.80 | ACAT2 (0.47) | TAAR1MAPTKDM4EGPR84MEN1 | |
| SCHEMBL16410834 | 0.79 | ACAT2 (0.36) | TAAR1MAPTKDM4EGPR84MEN1 | |
| SCHEMBL16410745 | 0.79 | TAAR1 (0.35) | TAAR1MAPTKDM4EGPR84MEN1 | |
| SCHEMBL16410752 | 0.75 | PDE7A (0.35) | TAAR1MAPTKDM4EKMT2A | |
| SCHEMBL16410809 | 0.73 | ACAT2 (0.35) | TAAR1 | |
| SCHEMBL16410791 | 0.73 | ACAT2 (0.33) | TAAR1 | |
| SCHEMBL17757594 | 0.71 | PDE7A (0.38) | TAAR1MAPTHDAC3HDAC1HDAC2 | |
| SCHEMBL17757303 | 0.70 | ACAT2 (0.48) | TAAR1MAPTHDAC3HDAC1HDAC2 | |
| SCHEMBL17757387 | 0.70 | ACAT2 (0.38) | TAAR1MAPTHDAC3HDAC1HDAC2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2015007730-A1 | SPIROQUINOXALINE DERIVATIVES AS INHIBITORS OF NON-APOPTOTIC REGULATED CELL-DEATH | Helmholtz Zentrum München - Deutsches Forschungszentrum für Gesundheit und Umwelt (GmbH) (DE) | 2015-01-22 | — | — | WO | disclosed |