Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TAAR1 | Q96RJ0 | 2/20 | 0.35 |
| ▸ | CASR | P41180 | 2/20 | 0.32 |
| ▸ | HTR1A | P08908 | 1/20 | 0.31 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.31 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.31 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.31 |
| ▸ | HRH2 | P25021 | 1/20 | 0.31 |
| ▸ | HTR2A | P28223 | 1/20 | 0.31 |
| ▸ | HTR2C | P28335 | 1/20 | 0.31 |
| ▸ | HRH1 | P35367 | 1/20 | 0.31 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.31 |
| ▸ | DRD3 | P35462 | 1/20 | 0.31 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.31 |
| ▸ | HTR2B | P41595 | 1/20 | 0.31 |
| ▸ | HTR5A | P47898 | 1/20 | 0.31 |
| ▸ | HTR6 | P50406 | 1/20 | 0.31 |
| ▸ | TMEM97 | Q5BJF2 | 1/20 | 0.31 |
| ▸ | GPR65 | Q8IYL9 | 1/20 | 0.31 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.31 |
| ▸ | MAPT | P10636 | 2/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16410852 | 0.93 | TAAR1 (0.40) | TAAR1HTR1AADRA2CSLC6A2HTR2C | |
| SCHEMBL16410752 | 0.82 | PDE7A (0.35) | TAAR1MAPTKDM4E | |
| SCHEMBL16410809 | 0.80 | ACAT2 (0.35) | TAAR1 | |
| SCHEMBL16410791 | 0.80 | ACAT2 (0.33) | TAAR1 | |
| SCHEMBL16410765 | 0.74 | ACAT2 (0.47) | TAAR1HTR2AHTR2CHTR2BMAPT | |
| SCHEMBL16410745 | 0.73 | TAAR1 (0.35) | TAAR1MAPTKDM4E | |
| SCHEMBL16410834 | 0.73 | ACAT2 (0.36) | TAAR1MAPTKDM4E | |
| SCHEMBL17757585 | 0.72 | PDE7A (0.36) | TAAR1CASRHTR1AADRA2BADRA2C | |
| SCHEMBL17757309 | 0.72 | ACAT2 (0.47) | TAAR1CASRHTR1AADRA2BADRA2C | |
| SCHEMBL17757555 | 0.71 | ACAT2 (0.36) | TAAR1CASRHTR1AADRA2BADRA2C |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2015007730-A1 | SPIROQUINOXALINE DERIVATIVES AS INHIBITORS OF NON-APOPTOTIC REGULATED CELL-DEATH | Helmholtz Zentrum München - Deutsches Forschungszentrum für Gesundheit und Umwelt (GmbH) (DE) | 2015-01-22 | — | — | WO | disclosed |