Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NQO1 | P15559 | 1/20 | 0.47 |
| ▸ | PARP10 | Q53GL7 | 1/20 | 0.46 |
| ▸ | PRSS1 | P07477 | 1/20 | 0.46 |
| ▸ | PRSS2 | P07478 | 1/20 | 0.46 |
| ▸ | PRSS3 | P35030 | 1/20 | 0.46 |
| ▸ | PDE4A | P27815 | 6/20 | 0.46 |
| ▸ | PDE4B | Q07343 | 6/20 | 0.46 |
| ▸ | PDE4C | Q08493 | 6/20 | 0.46 |
| ▸ | PDE4D | Q08499 | 6/20 | 0.46 |
| ▸ | NPC1 | O15118 | 2/20 | 0.44 |
| ▸ | PLK1 | P53350 | 1/20 | 0.44 |
| ▸ | PLA2G4B | P0C869 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.41 |
| ▸ | MAOB | P27338 | 1/20 | 0.41 |
| ▸ | LTA4H | P09960 | 1/20 | 0.41 |
| ▸ | GAA | P10253 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | RAB9A | P51151 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16413555 | 1.00 | NQO1 (0.47) | NQO1PARP10PRSS1PRSS2PRSS3 | |
| SCHEMBL16413553 | 1.00 | NQO1 (0.47) | NQO1PARP10PRSS1PRSS2PRSS3 | |
| SCHEMBL5194254 | 0.81 | PDE4A (0.60) | PDE4APDE4BPDE4CPDE4DNPSR1 | |
| SCHEMBL5194258 | 0.81 | PDE4A (0.60) | PDE4APDE4BPDE4CPDE4DNPSR1 | |
| SCHEMBL5194266 | 0.81 | PDE4A (0.60) | PDE4APDE4BPDE4CPDE4DNPSR1 | |
| SCHEMBL1930630 | 0.80 | NQO1 (0.47) | NQO1PARP10PRSS1PRSS2PRSS3 | |
| SCHEMBL1930629 | 0.80 | NQO1 (0.47) | NQO1PARP10PRSS1PRSS2PRSS3 | |
| SCHEMBL5197081 | 0.74 | CA2 (0.45) | PARP10MAOBALDH1A1 | |
| SCHEMBL6611275 | 0.74 | CA2 (0.45) | PARP10MAOBALDH1A1 | |
| SCHEMBL5197078 | 0.74 | CA2 (0.45) | PARP10MAOBALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9688653-B2 | Ethoxyphenyl thienyl compounds and methods for the treatment of bacterial infections | DUKE UNIVERSITY (US) | 2017-06-27 | — | — | US | disclosed |
| US-20150031658-A1 | ETHOXYPHENYL THIENYL COMPOUNDS AND METHODS FOR THE TREATMENT OF BACTERIAL INFECTIONS | UNIV DUKE (US) | 2015-01-29 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20150031658-A1 | ETHOXYPHENYL THIENYL COMPOUNDS AND METHODS FOR THE TREATMENT OF BACTERIAL INFECTIONS | GGPS1, FDPS, FNTA | NQO1 20/4885PARP10 1414/4885PRSS1 1232/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.