Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 2/20 | 0.53 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.53 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.53 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.53 |
| ▸ | LMNA | P02545 | 1/20 | 0.53 |
| ▸ | HPGD | P15428 | 1/20 | 0.53 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.53 |
| ▸ | BLM | P54132 | 1/20 | 0.53 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.53 |
| ▸ | ESRRG | P62508 | 1/20 | 0.52 |
| ▸ | TRPV1 | Q8NER1 | 2/20 | 0.47 |
| ▸ | ERCC1 | P07992 | 1/20 | 0.47 |
| ▸ | ERCC4 | Q92889 | 1/20 | 0.47 |
| ▸ | MEN1 | O00255 | 2/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.46 |
| ▸ | GAA | P10253 | 1/20 | 0.46 |
| ▸ | ALPL | P05186 | 1/20 | 0.46 |
| ▸ | APP | P05067 | 1/20 | 0.44 |
| ▸ | CA1 | P00915 | 1/20 | 0.43 |
| ▸ | CA2 | P00918 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20188223 | 0.87 | MAPT (0.53) | MAPTHSD17B10KDM4EALDH1A1LMNA | |
| SCHEMBL6420228 | 0.84 | MAPT (0.72) | MAPTHSD17B10KDM4EALDH1A1LMNA | |
| SCHEMBL22772331 | 0.83 | MT-CO2 (0.49) | ERCC1ERCC4 | |
| SCHEMBL6184638 | 0.81 | MAPT (0.58) | MAPTHSD17B10KDM4EALDH1A1LMNA | |
| SCHEMBL27944339 | 0.80 | PLK4 (0.55) | MAPTHSD17B10KDM4EALDH1A1LMNA | |
| SCHEMBL3627156 | 0.79 | SMN1; SMN2 (0.55) | MAPTLMNATRPV1GAACA1 | |
| SCHEMBL31354763 | 0.79 | RAB9A (0.44) | CA1CA2 | |
| SCHEMBL29444602 | 0.79 | ESRRG (0.45) | MAPTHSD17B10KDM4EALDH1A1LMNA | |
| SCHEMBL19235667 | 0.79 | ESRRG (0.45) | MAPTHSD17B10KDM4EALDH1A1LMNA | |
| SCHEMBL1338001 | 0.78 | KDM4E (0.52) | MAPTHSD17B10KDM4EALDH1A1LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-111051309-B | Triazolotriazine derivatives useful as A2A receptor antagonists | 浙江春禾医药科技有限公司 | 2023-05-26 | — | — | CN | disclosed |
| CN-111051309-A | Triazolotriazine derivatives useful as A2A receptor antagonists | 浙江春禾医药科技有限公司 | 2020-04-21 | — | — | CN | disclosed |
| WO-2015013318-A1 | BORON-CONTAINING SMALL MOLECULES | ANACOR PHARMACEUTICALS, INC. (US) | 2015-01-29 | — | — | WO | disclosed |