Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 5/20 | 0.58 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.58 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.58 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.58 |
| ▸ | HIF1A | Q16665 | 2/20 | 0.58 |
| ▸ | LMNA | P02545 | 2/20 | 0.58 |
| ▸ | HPGD | P15428 | 2/20 | 0.58 |
| ▸ | BLM | P54132 | 2/20 | 0.58 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.58 |
| ▸ | ESRRG | P62508 | 1/20 | 0.55 |
| ▸ | ALPL | P05186 | 1/20 | 0.54 |
| ▸ | ESR1 | P03372 | 1/20 | 0.53 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.53 |
| ▸ | TRPV1 | Q8NER1 | 2/20 | 0.48 |
| ▸ | MEN1 | O00255 | 2/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.48 |
| ▸ | ERCC1 | P07992 | 1/20 | 0.48 |
| ▸ | ERCC4 | Q92889 | 1/20 | 0.48 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.47 |
| ▸ | TP53 | P04637 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15762685 | 0.88 | KDM4E (0.76) | MAPTHSD17B10ALDH1A1KDM4EHIF1A | |
| SCHEMBL6420228 | 0.86 | MAPT (0.72) | MAPTHSD17B10ALDH1A1KDM4EHIF1A | |
| SCHEMBL11083226 | 0.85 | MAPT (0.54) | MAPTHSD17B10ALDH1A1KDM4EHIF1A | |
| SCHEMBL6046352 | 0.85 | ESRRG (0.64) | MAPTALDH1A1KDM4ELMNAESRRG | |
| SCHEMBL18997747 | 0.84 | ESRRG (0.56) | MAPTHSD17B10ALDH1A1KDM4EHIF1A | |
| SCHEMBL19842170 | 0.82 | CNR1 (0.61) | MAPTALDH1A1KDM4EHPGDMEN1 | |
| SCHEMBL12246749 | 0.82 | MAPT (0.65) | MAPTHSD17B10ALDH1A1KDM4EHIF1A | |
| SCHEMBL17646473 | 0.81 | CNR1 (0.46) | MAPTHSD17B10ALDH1A1KDM4EHIF1A | |
| SCHEMBL27944339 | 0.81 | PLK4 (0.55) | MAPTHSD17B10ALDH1A1KDM4EHIF1A | |
| SCHEMBL16415751 | 0.81 | MAPT (0.53) | MAPTHSD17B10ALDH1A1KDM4EHIF1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1562595-A1 | DIARYL ETHERS AS OPIOID RECEPTOR ANTAGONISTS | ELI LILLY AND COMPANY (US) | 2005-08-17 | — | — | EP | disclosed |
| WO-2004026305-A1 | DIARYL ETHERS AS OPIOID RECEPTOR ANTAGONIST | ELI LILLY AND COMPANY (US) | 2004-04-01 | — | — | WO | disclosed |