Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.46 |
| ▸ | LMNA | P02545 | 1/20 | 0.44 |
| ▸ | GAA | P10253 | 1/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.42 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.38 |
| ▸ | TP53 | P04637 | 1/20 | 0.36 |
| ▸ | PTGDR2 | Q9Y5Y4 | 1/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.34 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.34 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.34 |
| ▸ | RAB9A | P51151 | 1/20 | 0.34 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.33 |
| ▸ | CXCR3 | P49682 | 1/20 | 0.33 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
| ▸ | POLB | P06746 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3588529 | 0.79 | ALDH1A1 (0.50) | ALDH1A1LMNAGAASMN1; SMN2ALOX15 | |
| Hydrochloric Acid SCHEMBL1374124 | 0.77 | ALDH1A1 (0.48) | ALDH1A1LMNAGAASMN1; SMN2ALOX15 | |
| SCHEMBL21960147 | 0.76 | ADORA2A (0.33) | — | |
| SCHEMBL16415983 | 0.70 | LMNA (0.49) | ALDH1A1LMNAGAASMN1; SMN2ALOX15 | |
| SCHEMBL20223332 | 0.68 | KDM4C (0.54) | ALDH1A1LMNAGAASMN1; SMN2ALOX15 | |
| SCHEMBL9342106 | 0.67 | — | — | |
| SCHEMBL17927903 | 0.67 | LMNA (0.41) | ALDH1A1LMNAGAASMN1; SMN2ALOX15 | |
| SCHEMBL19007302 | 0.67 | ALDH1A1 (0.65) | ALDH1A1LMNAGAAALOX15PTGDR2 | |
| SCHEMBL13031308 | 0.66 | CYP19A1 (0.58) | ALDH1A1LMNASMN1; SMN2ALOX15KDM4E | |
| SCHEMBL7121270 | 0.64 | LMNA (0.42) | ALDH1A1LMNAGAAALOX15MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 14 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-107250133-B | Hydroxyalkyl piperazine derivatives as CXCR3 receptor modulators | 爱杜西亚药品有限公司 | 2020-09-15 | — | — | CN | disclosed |
| US-10259807-B2 | 1-(piperazin-1-yl)-2-([1,2,4]triazol-1-yl)-ethanone derivatives | IDORSIA PHARMACEUTICALS LTD. (SE) | 2019-04-16 | — | — | US | disclosed |
| CN-105658649-B | 1- (piperazine -1- base) -2- ([1,2,4] triazol-1-yl)-ethanone derivatives | 爱杜西亚药品有限公司 | 2019-03-22 | — | — | CN | disclosed |
| EP-3245203-B1 | HYDROXYALKYL-PIPERAZINE DERIVATIVES AS CXCR3 RECEPTOR MODULATORS | IDORSIA PHARMACEUTICALS LTD (CH) | 2018-11-14 | — | — | EP | disclosed |
| US-10053457-B2 | Hydroxyalkyl-piperazine derivatives as CXCR3 receptor modulators | IDORSIA PHARMACEUTICALS LTD. (CH) | 2018-08-21 | — | — | US | disclosed |
| EP-3024832-B1 | 1-(PIPERAZIN-1-YL)-2-([1,2,4]TRIAZOL-1-YL)-ETHANONE DERIVATIVES | IDORSIA PHARMACEUTICALS LTD (CH) | 2018-03-28 | — | — | EP | disclosed |
| US-20180009799-A1 | HYDROXYALKYL-PIPERAZINE DERIVATIVES AS CXCR3 RECEPTOR MODULATORS | ACTELION PHARMACEUTICALS LTD (CH) | 2018-01-11 | — | — | US | disclosed |
| EP-3245203-A1 | HYDROXYALKYL-PIPERAZINE DERIVATIVES AS CXCR3 RECEPTOR MODULATORS | Idorsia Pharmaceuticals Ltd (CH) | 2017-11-22 | — | — | EP | disclosed |
| CN-107250133-A | Hydroxyalkyl piperazine derivatives as CXCR3 receptor modulators | 爱杜西亚药品有限公司 | 2017-10-13 | — | — | CN | disclosed |
| WO-2016113344-A1 | HYDROXYALKYL-PIPERAZINE DERIVATIVES AS CXCR3 RECEPTOR MODULATORS | ACTELION PHARMACEUTICALS LTD (CH) | 2016-07-21 | — | — | WO | disclosed |
| US-20160176862-A1 | 1-(PIPERAZIN-1-YL)-2-([1,2,4]TRIAZOL-1-YL)-ETHANONE DERIVATIVES | IDORSIA PHARMACEUTICALS LTD (CH) | 2016-06-23 | — | — | US | disclosed |
| CN-105658649-A | 1-(piperazin-1-yl)-2-([1,2,4]triazol-1-yl)-ethanone derivatives | 埃科特莱茵药品有限公司 | 2016-06-08 | — | — | CN | disclosed |
| EP-3024832-A1 | 1-(PIPERAZIN-1-YL)-2-([1,2,4]TRIAZOL-1-YL)-ETHANONE DERIVATIVES | Actelion Pharmaceuticals Ltd. (CH) | 2016-06-01 | — | — | EP | disclosed |
| WO-2015011099-A1 | 1-(PIPERAZIN-1-YL)-2-([1,2,4]TRIAZOL-1-YL)-ETHANONE DERIVATIVES | ACTELION PHARMACEUTICALS LTD (CH) | 2015-01-29 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10053457-B2 | Hydroxyalkyl-piperazine derivatives as CXCR3 receptor modulators | CXCR3, CXCR1, CXCR2 | ALDH1A1 1096/4885LMNA 4610/4885GAA 4790/4885 |
| US-20180009799-A1 | HYDROXYALKYL-PIPERAZINE DERIVATIVES AS CXCR3 RECEPTOR MODULATORS | CXCR3, CXCR1, CXCR2 | ALDH1A1 1096/4885LMNA 4610/4885GAA 4790/4885 |
| US-10259807-B2 | 1-(piperazin-1-yl)-2-([1,2,4]triazol-1-yl)-ethanone derivatives | CXCR3, CXCR1, CXCR2 | ALDH1A1 1093/4885LMNA 4374/4885GAA 4502/4885 |
| US-20160176862-A1 | 1-(PIPERAZIN-1-YL)-2-([1,2,4]TRIAZOL-1-YL)-ETHANONE DERIVATIVES | CXCR3, CXCR1, CXCR2 | ALDH1A1 1093/4885LMNA 4374/4885GAA 4502/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.