SCHEMBL164192

SCHEMBL164192

O=C(O)[C@H](Cc1c[nH]c2ccccc12)N1C(=O)c2ccccc2C1=O

nearest known ligand 1.00 ✓ in ChEMBL — recovers established targets

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
KMT2A Q03164 4/20 1.00
DNMT1 P26358 3/20 1.00
CYP2C19 P33261 1/20 1.00
DNMT3B Q9UBC3 1/20 1.00
PKM P14618 1/20 1.00
STAT3 P40763 1/20 0.68
MAPT P10636 4/20 0.66
MEN1 O00255 3/20 0.66
GAA P10253 3/20 0.60
SMN1; SMN2 Q16637 1/20 0.59
ALDH1A1 P00352 1/20 0.58
KDM4E B2RXH2 2/20 0.58
HIF1A Q16665 2/20 0.58
POLB P06746 2/20 0.58
APAF1 O14727 1/20 0.58
RECQL P46063 1/20 0.58
L3MBTL1 Q9Y468 1/20 0.58
LMNA P02545 1/20 0.58
MPO P05164 1/20 0.58
TSHR P16473 1/20 0.58

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL11949518 1.00 KMT2A (1.00) KMT2ADNMT1CYP2C19DNMT3BPKM
SCHEMBL562060 1.00 KMT2A (1.00) KMT2ADNMT1CYP2C19DNMT3BPKM
SCHEMBL30167914 1.00 KMT2A (1.00) KMT2ADNMT1CYP2C19DNMT3BPKM
SCHEMBL28518031 0.90 DNMT1 (0.81) KMT2ADNMT1CYP2C19DNMT3BPKM
SCHEMBL5306820 0.89 KMT2A (0.80) KMT2ADNMT1CYP2C19DNMT3BPKM
SCHEMBL5306824 0.89 KMT2A (0.80) KMT2ADNMT1CYP2C19DNMT3BPKM
SCHEMBL19244077 0.87 DNMT1 (0.76) KMT2ADNMT1CYP2C19DNMT3BPKM
SCHEMBL30382095 0.87 DNMT1 (0.76) KMT2ADNMT1CYP2C19DNMT3BPKM
SCHEMBL21439464 0.87 DNMT1 (0.76) KMT2ADNMT1CYP2C19DNMT3BPKM
SCHEMBL14174620 0.87 KMT2A (0.77) KMT2ADNMT1CYP2C19DNMT3BPKM

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 780 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-12637498-B2 PDLIM2 as a biomarker for cancer and as an anti-cancer treatment target University of Pittsburgh—of the Commonwealth System of Higher Education (US) 2026-05-26 US claimed
CN-122070932-A Application of combination of decitabine and anti-HER 2 antibody in preparation of medicines for treating tumors 上海交通大学 2026-05-22 CN claimed
CN-116355836-B Bile duct trunk cell expansion or passage system and application thereof 上海市东方医院(同济大学附属东方医院) 2026-05-19 CN claimed
EP-4729064-A1 DE-DIFFERENTIATED FIBROBLAST-CONDITIONED MEDIA FOR TREATING OR PREVENTING DISC DEGENERATION FibroBiologics, Inc. (US) 2026-04-22 EP claimed
EP-3787647-B1 DE-DIFFERENTIATED FIBROBLAST-CONDITIONED MEDIA FOR TREATING OR PREVENTING DISC DEGENERATION FIBROBIOLOGICS INC (US) 2026-04-15 EP claimed
EP-4719447-A2 METHOD TO GENERATE INDUCED RETINAL PROGENITOR CELLS AND TREATMENT USING SUCH CELLS Academia Sinica (TW) 2026-04-08 EP claimed
US-20250311689-A1 SEEDLING GERMINATION AND GROWTH CONDITIONS PIONEER HI-BRED INTERNATIONAL, INC. (US) 2025-10-09 US claimed
US-12427128-B2 Sensorineural hair cell differentiation MASSACHUSETTS EYE AND EAR INFIRMARY (US) 2025-09-30 US claimed
CN-120118841-A Composition, induction method and application of chemical reprogramming induction functional ciRPE cells 瓯江实验室 2025-06-10 CN claimed
US-20250179578-A1 METHOD FOR PREDICTING REACTIVITY TO ANTICANCER DRUGS BY ANALYZING GENOMIC DNA METHYLATION STATUS SEOUL NATIONAL UNIVERSITY HOSPITAL (KR) 2025-06-05 US claimed
US-20160145581-A1 COMPOSITIONS AND METHODS FOR REPROGRAMING NON-PLURIPOTENT CELLS INTO PLURIPOTENT STEM CELLS HONG GUAN, LTD. (CN) 2016-05-26 US claimed
EP-3019596-A1 COMPOSITIONS AND METHODS FOR REPROGRAMING NON- PLURIPOTENT CELLS INTO PLURIPOTENT STEM CELLS Hong Guan Ltd. (CN) 2016-05-18 EP claimed
US-20150259649-A1 CELLULAR COMPOSITIONS USED TO RESTORE STEM CELL OR PROGENITOR CELL FUNCTION AND METHODS RELATED THERETO NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT 2015-09-17 US claimed
WO-2015003643-A1 COMPOSITIONS AND METHODS FOR REPROGRAMING NON- PLURIPOTENT CELLS INTO PLURIPOTENT STEM CELLS HONG GUAN LTD. (CN) 2015-01-15 WO claimed
US-20140255359-A1 METHODS, KITS, AND COMPOSITIONS FOR STEM CELL SELF-RENEWAL STOWERS INSTITUTE FOR MEDICAL RESEARCH 2014-09-11 US claimed
WO-2013059357-A1 METHODS, KITS, AND COMPOSITIONS FOR STEM CELL SELF-RENEWAL STOWERS INSTITUTE FOR MEDICAL RESEARCH (US) 2013-04-25 WO claimed
WO-2012038417-A1 SUBSTITUTED AMINO - BENZOIC ACID DERIVATIVES AS INHIBITORS OF DNA METHYLTRANSFERASES INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE (INSERM) (FR) 2012-03-29 WO claimed
US-20100305059-A1 COMPOSITION AND METHODS FOR THE TREATMENT OF MYELODYSPLASTIC SYNDROME AND ACUTE MYELOID LEUKEMIA TEMPLE UNIVERSITY-OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION (US) 2010-12-02 US claimed
WO-2008027049-A1 COMPOSITION AND METHODS FOR THE TREATMENT OF MYELODYSPLASTIC SYNDROME AND ACUTE MYELOID LEUKEMIA TEMPLE UNIVERSITY - OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION (US) 2008-03-06 WO claimed
US-4283337-A Process for the purification of tryptophane and derivatives of tryptophane DEUTSCHE GOLD UND- SILBER-SCHEIDEANSTALT VORMALS ROESSLER (DE) 1981-08-11 US claimed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20160145581-A1 COMPOSITIONS AND METHODS FOR REPROGRAMING NON-PLURIPOTENT CELLS INTO PLURIPOTENT STEM CELLS AHCY, GSKIP, AHCYL1 KMT2A 522/4885DNMT1 241/4885CYP2C19 4463/4885
US-20100305059-A1 COMPOSITION AND METHODS FOR THE TREATMENT OF MYELODYSPLASTIC SYNDROME AND ACUTE MYELOID LEUKEMIA DNMT3A, TET2, MCL1 KMT2A 17/4885DNMT1 4/4885CYP2C19 1924/4885
US-20150259649-A1 CELLULAR COMPOSITIONS USED TO RESTORE STEM CELL OR PROGENITOR CELL FUNCTION AND METHODS RELATED THERETO BMI1, DNMT1, DNMT3A KMT2A 176/4885DNMT1 2/4885CYP2C19 4884/4885
US-12637498-B2 PDLIM2 as a biomarker for cancer and as an anti-cancer treatment target HDAC2, HDAC1, HDAC11 KMT2A 48/4885DNMT1 44/4885CYP2C19 4742/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.